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A fourteen-lncRNA risk score system for prognostic prediction of patients with non-small cell lung cancer
Growing evidence has underscored long non-coding RNAs (lncRNAs) serving as potential biomarkers for cancer prognosis. However, systematic tracking of a lncRNA signature for prognosis prediction in non-small cell lung cancer (NSCLC) has not been accomplished yet. Here, comprehensive analysis with dif...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
IOS Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7739968/ https://www.ncbi.nlm.nih.gov/pubmed/32831192 http://dx.doi.org/10.3233/CBM-190505 |
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author | Song, Jia-Yi Li, Xiao-Ping Qin, Xiu-Jiao Zhang, Jing-Dong Zhao, Jian-Yu Wang, Rui |
author_facet | Song, Jia-Yi Li, Xiao-Ping Qin, Xiu-Jiao Zhang, Jing-Dong Zhao, Jian-Yu Wang, Rui |
author_sort | Song, Jia-Yi |
collection | PubMed |
description | Growing evidence has underscored long non-coding RNAs (lncRNAs) serving as potential biomarkers for cancer prognosis. However, systematic tracking of a lncRNA signature for prognosis prediction in non-small cell lung cancer (NSCLC) has not been accomplished yet. Here, comprehensive analysis with differential gene expression analysis, univariate and multivariate Cox regression analysis based on The Cancer Genome Atlas (TCGA) database was performed to identify the lncRNA signature for prediction of the overall survival of NSCLC patients. A risk-score model based on a 14-lncRNA signature was identified, which could classify patients into high-risk and low-risk groups and show poor and improved outcomes, respectively. The receiver operating characteristic (ROC) curve revealed that the risk-score model has good performance with high AUC value. Multivariate Cox’s regression model and stratified analysis indicated that the risk-score was independent of other clinicopathological prognostic factors. Furthermore, the risk-score model was competent for the prediction of metastasis-free survival in NSCLC patients. Moreover, the risk-score model was applicable for prediction of the overall survival in the other 30 caner types of TCGA. Our study highlighted the significant implications of lncRNAs as prognostic predictors in NSCLC. We hope the lncRNA signature could contribute to personalized therapy decisions in the future. |
format | Online Article Text |
id | pubmed-7739968 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | IOS Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-77399682020-12-18 A fourteen-lncRNA risk score system for prognostic prediction of patients with non-small cell lung cancer Song, Jia-Yi Li, Xiao-Ping Qin, Xiu-Jiao Zhang, Jing-Dong Zhao, Jian-Yu Wang, Rui Cancer Biomark Research Article Growing evidence has underscored long non-coding RNAs (lncRNAs) serving as potential biomarkers for cancer prognosis. However, systematic tracking of a lncRNA signature for prognosis prediction in non-small cell lung cancer (NSCLC) has not been accomplished yet. Here, comprehensive analysis with differential gene expression analysis, univariate and multivariate Cox regression analysis based on The Cancer Genome Atlas (TCGA) database was performed to identify the lncRNA signature for prediction of the overall survival of NSCLC patients. A risk-score model based on a 14-lncRNA signature was identified, which could classify patients into high-risk and low-risk groups and show poor and improved outcomes, respectively. The receiver operating characteristic (ROC) curve revealed that the risk-score model has good performance with high AUC value. Multivariate Cox’s regression model and stratified analysis indicated that the risk-score was independent of other clinicopathological prognostic factors. Furthermore, the risk-score model was competent for the prediction of metastasis-free survival in NSCLC patients. Moreover, the risk-score model was applicable for prediction of the overall survival in the other 30 caner types of TCGA. Our study highlighted the significant implications of lncRNAs as prognostic predictors in NSCLC. We hope the lncRNA signature could contribute to personalized therapy decisions in the future. IOS Press 2020-11-20 /pmc/articles/PMC7739968/ /pubmed/32831192 http://dx.doi.org/10.3233/CBM-190505 Text en © 2020 – IOS Press and the authors. All rights reserved https://creativecommons.org/licenses/by-nc/4.0/ This article is published online with Open Access and distributed under the terms of the Creative Commons Attribution License (CC BY 4.0). |
spellingShingle | Research Article Song, Jia-Yi Li, Xiao-Ping Qin, Xiu-Jiao Zhang, Jing-Dong Zhao, Jian-Yu Wang, Rui A fourteen-lncRNA risk score system for prognostic prediction of patients with non-small cell lung cancer |
title | A fourteen-lncRNA risk score system for prognostic prediction of patients with non-small cell lung cancer |
title_full | A fourteen-lncRNA risk score system for prognostic prediction of patients with non-small cell lung cancer |
title_fullStr | A fourteen-lncRNA risk score system for prognostic prediction of patients with non-small cell lung cancer |
title_full_unstemmed | A fourteen-lncRNA risk score system for prognostic prediction of patients with non-small cell lung cancer |
title_short | A fourteen-lncRNA risk score system for prognostic prediction of patients with non-small cell lung cancer |
title_sort | fourteen-lncrna risk score system for prognostic prediction of patients with non-small cell lung cancer |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7739968/ https://www.ncbi.nlm.nih.gov/pubmed/32831192 http://dx.doi.org/10.3233/CBM-190505 |
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