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Moonshots for aging
As the global population ages, there is increased interest in living longer and improving one’s quality of life in later years. However, studying aging – the decline in body function – is expensive and time-consuming. And despite research success to make model organisms live longer, there still are...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
IOS Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7740370/ https://www.ncbi.nlm.nih.gov/pubmed/33344796 http://dx.doi.org/10.3233/NHA-190064 |
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author | Kumar, Sandeep Peterson, Timothy R. |
author_facet | Kumar, Sandeep Peterson, Timothy R. |
author_sort | Kumar, Sandeep |
collection | PubMed |
description | As the global population ages, there is increased interest in living longer and improving one’s quality of life in later years. However, studying aging – the decline in body function – is expensive and time-consuming. And despite research success to make model organisms live longer, there still aren’t really any feasible solutions for delaying aging in humans. With space travel, scientists and engineers couldn’t know what it would take to get to the moon. They had to extrapolate from theory and shorter-range tests. Perhaps with aging, we need a similar moonshot philosophy. And though “shot” might imply medicine, perhaps we need to think beyond medical interventions. Like the moon once was, we seem a long way away from provable therapies to increase human healthspan (the healthy period of one’s life) or lifespan (how long one lives). This review therefore focuses on radical proposals. We hope it might stimulate discussion on what we might consider doing significantly differently than ongoing aging research. |
format | Online Article Text |
id | pubmed-7740370 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | IOS Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-77403702020-12-18 Moonshots for aging Kumar, Sandeep Peterson, Timothy R. Nutr Healthy Aging Review As the global population ages, there is increased interest in living longer and improving one’s quality of life in later years. However, studying aging – the decline in body function – is expensive and time-consuming. And despite research success to make model organisms live longer, there still aren’t really any feasible solutions for delaying aging in humans. With space travel, scientists and engineers couldn’t know what it would take to get to the moon. They had to extrapolate from theory and shorter-range tests. Perhaps with aging, we need a similar moonshot philosophy. And though “shot” might imply medicine, perhaps we need to think beyond medical interventions. Like the moon once was, we seem a long way away from provable therapies to increase human healthspan (the healthy period of one’s life) or lifespan (how long one lives). This review therefore focuses on radical proposals. We hope it might stimulate discussion on what we might consider doing significantly differently than ongoing aging research. IOS Press 2020-11-03 /pmc/articles/PMC7740370/ /pubmed/33344796 http://dx.doi.org/10.3233/NHA-190064 Text en © 2020 – IOS Press and the authors. All rights reserved https://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Kumar, Sandeep Peterson, Timothy R. Moonshots for aging |
title | Moonshots for aging |
title_full | Moonshots for aging |
title_fullStr | Moonshots for aging |
title_full_unstemmed | Moonshots for aging |
title_short | Moonshots for aging |
title_sort | moonshots for aging |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7740370/ https://www.ncbi.nlm.nih.gov/pubmed/33344796 http://dx.doi.org/10.3233/NHA-190064 |
work_keys_str_mv | AT kumarsandeep moonshotsforaging AT petersontimothyr moonshotsforaging |