Cargando…

Late-Onset Intermittent Fasting Decreases Aging-Related Frailty

Global average life expectancy continues to rise. As aging increases likelihoods of exhibiting geriatric syndromes (a.k.a. frailty), there is a need for effective anti-aging treatments. Multiple studies have shown the positive effects of dietary restriction (DR) on lifespan in various model organism...

Descripción completa

Detalles Bibliográficos
Autores principales: Henderson, Yoko, Bithi, Nazmin, Link, Christopher, Yang, Jie, Hine, Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7740766/
http://dx.doi.org/10.1093/geroni/igaa057.411
_version_ 1783623607704879104
author Henderson, Yoko
Bithi, Nazmin
Link, Christopher
Yang, Jie
Hine, Christopher
author_facet Henderson, Yoko
Bithi, Nazmin
Link, Christopher
Yang, Jie
Hine, Christopher
author_sort Henderson, Yoko
collection PubMed
description Global average life expectancy continues to rise. As aging increases likelihoods of exhibiting geriatric syndromes (a.k.a. frailty), there is a need for effective anti-aging treatments. Multiple studies have shown the positive effects of dietary restriction (DR) on lifespan in various model organisms. However, DR is not widely implemented in older adults due to issues with patient compliance and the overall lack of understanding on the effects of DR initiated later in life. Thus, the present study tested whether late-life DR, specifically Every-Other-Day (EOD) fasting, attenuates aging-related frailty using a modified and simplified frailty index in mice. Briefly, 20-month old male and female C57BL/6 mice (human equivalent of 65 years) that had been on a control chow diet ad libitum during adulthood were placed on EOD fasting or ad libitum feeding for 2.5 months. Their frailty index was identified using an indirect calorimeter, glucose tolerance test, novel object place recognition test, forelimb grip strength meter, and rotarod. We found that late-life EOD fasting decreased overall caloric intake in males but not in females. In addition, EOD fasting significantly improved metabolic, musculoskeletal, and cognitive endpoints in male mice, but enhanced only some of these in female mice. Furthermore, EOD fasting improved hydrogen sulfide (H2S) production capacity and its associated sulfhydration signaling in tissues, which positively correlated with improvements in frailty measures. We conclude that EOD fasting implemented late in life can have therapeutic potential in the clinic. We are currently investigating the necessity of H2S production for DR mediated benefits and longevity.
format Online
Article
Text
id pubmed-7740766
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-77407662020-12-21 Late-Onset Intermittent Fasting Decreases Aging-Related Frailty Henderson, Yoko Bithi, Nazmin Link, Christopher Yang, Jie Hine, Christopher Innov Aging Abstracts Global average life expectancy continues to rise. As aging increases likelihoods of exhibiting geriatric syndromes (a.k.a. frailty), there is a need for effective anti-aging treatments. Multiple studies have shown the positive effects of dietary restriction (DR) on lifespan in various model organisms. However, DR is not widely implemented in older adults due to issues with patient compliance and the overall lack of understanding on the effects of DR initiated later in life. Thus, the present study tested whether late-life DR, specifically Every-Other-Day (EOD) fasting, attenuates aging-related frailty using a modified and simplified frailty index in mice. Briefly, 20-month old male and female C57BL/6 mice (human equivalent of 65 years) that had been on a control chow diet ad libitum during adulthood were placed on EOD fasting or ad libitum feeding for 2.5 months. Their frailty index was identified using an indirect calorimeter, glucose tolerance test, novel object place recognition test, forelimb grip strength meter, and rotarod. We found that late-life EOD fasting decreased overall caloric intake in males but not in females. In addition, EOD fasting significantly improved metabolic, musculoskeletal, and cognitive endpoints in male mice, but enhanced only some of these in female mice. Furthermore, EOD fasting improved hydrogen sulfide (H2S) production capacity and its associated sulfhydration signaling in tissues, which positively correlated with improvements in frailty measures. We conclude that EOD fasting implemented late in life can have therapeutic potential in the clinic. We are currently investigating the necessity of H2S production for DR mediated benefits and longevity. Oxford University Press 2020-12-16 /pmc/articles/PMC7740766/ http://dx.doi.org/10.1093/geroni/igaa057.411 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of The Gerontological Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstracts
Henderson, Yoko
Bithi, Nazmin
Link, Christopher
Yang, Jie
Hine, Christopher
Late-Onset Intermittent Fasting Decreases Aging-Related Frailty
title Late-Onset Intermittent Fasting Decreases Aging-Related Frailty
title_full Late-Onset Intermittent Fasting Decreases Aging-Related Frailty
title_fullStr Late-Onset Intermittent Fasting Decreases Aging-Related Frailty
title_full_unstemmed Late-Onset Intermittent Fasting Decreases Aging-Related Frailty
title_short Late-Onset Intermittent Fasting Decreases Aging-Related Frailty
title_sort late-onset intermittent fasting decreases aging-related frailty
topic Abstracts
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7740766/
http://dx.doi.org/10.1093/geroni/igaa057.411
work_keys_str_mv AT hendersonyoko lateonsetintermittentfastingdecreasesagingrelatedfrailty
AT bithinazmin lateonsetintermittentfastingdecreasesagingrelatedfrailty
AT linkchristopher lateonsetintermittentfastingdecreasesagingrelatedfrailty
AT yangjie lateonsetintermittentfastingdecreasesagingrelatedfrailty
AT hinechristopher lateonsetintermittentfastingdecreasesagingrelatedfrailty