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Time-dependent spatial specificity of high-resolution fMRI: insights into mesoscopic neurovascular coupling
High-resolution functional magnetic resonance imaging (fMRI) is becoming increasingly popular because of the growing availability of ultra-high magnetic fields which are capable of improving sensitivity and spatial resolution. However, it is debatable whether increased spatial resolutions for haemod...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7741035/ https://www.ncbi.nlm.nih.gov/pubmed/33190606 http://dx.doi.org/10.1098/rstb.2019.0623 |
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author | Fukuda, Mitsuhiro Poplawsky, Alexander J. Kim, Seong-Gi |
author_facet | Fukuda, Mitsuhiro Poplawsky, Alexander J. Kim, Seong-Gi |
author_sort | Fukuda, Mitsuhiro |
collection | PubMed |
description | High-resolution functional magnetic resonance imaging (fMRI) is becoming increasingly popular because of the growing availability of ultra-high magnetic fields which are capable of improving sensitivity and spatial resolution. However, it is debatable whether increased spatial resolutions for haemodynamic-based techniques, like fMRI, can accurately detect the true location of neuronal activity. We have addressed this issue in functional columns and layers of animals with haemoglobin-based optical imaging and different fMRI contrasts, such as blood oxygenation level-dependent, cerebral blood flow and cerebral blood volume fMRI. In this review, we describe empirical evidence primarily from our own studies on how well these fMRI signals are spatially specific to the neuronally active site and discuss insights into neurovascular coupling at the mesoscale. This article is part of the theme issue ‘Key relationships between non-invasive functional neuroimaging and the underlying neuronal activity’. |
format | Online Article Text |
id | pubmed-7741035 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Royal Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-77410352020-12-18 Time-dependent spatial specificity of high-resolution fMRI: insights into mesoscopic neurovascular coupling Fukuda, Mitsuhiro Poplawsky, Alexander J. Kim, Seong-Gi Philos Trans R Soc Lond B Biol Sci Articles High-resolution functional magnetic resonance imaging (fMRI) is becoming increasingly popular because of the growing availability of ultra-high magnetic fields which are capable of improving sensitivity and spatial resolution. However, it is debatable whether increased spatial resolutions for haemodynamic-based techniques, like fMRI, can accurately detect the true location of neuronal activity. We have addressed this issue in functional columns and layers of animals with haemoglobin-based optical imaging and different fMRI contrasts, such as blood oxygenation level-dependent, cerebral blood flow and cerebral blood volume fMRI. In this review, we describe empirical evidence primarily from our own studies on how well these fMRI signals are spatially specific to the neuronally active site and discuss insights into neurovascular coupling at the mesoscale. This article is part of the theme issue ‘Key relationships between non-invasive functional neuroimaging and the underlying neuronal activity’. The Royal Society 2021-01-04 2020-11-16 /pmc/articles/PMC7741035/ /pubmed/33190606 http://dx.doi.org/10.1098/rstb.2019.0623 Text en © 2020 The Authors. http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/http://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited. |
spellingShingle | Articles Fukuda, Mitsuhiro Poplawsky, Alexander J. Kim, Seong-Gi Time-dependent spatial specificity of high-resolution fMRI: insights into mesoscopic neurovascular coupling |
title | Time-dependent spatial specificity of high-resolution fMRI: insights into mesoscopic neurovascular coupling |
title_full | Time-dependent spatial specificity of high-resolution fMRI: insights into mesoscopic neurovascular coupling |
title_fullStr | Time-dependent spatial specificity of high-resolution fMRI: insights into mesoscopic neurovascular coupling |
title_full_unstemmed | Time-dependent spatial specificity of high-resolution fMRI: insights into mesoscopic neurovascular coupling |
title_short | Time-dependent spatial specificity of high-resolution fMRI: insights into mesoscopic neurovascular coupling |
title_sort | time-dependent spatial specificity of high-resolution fmri: insights into mesoscopic neurovascular coupling |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7741035/ https://www.ncbi.nlm.nih.gov/pubmed/33190606 http://dx.doi.org/10.1098/rstb.2019.0623 |
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