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Does Inflammation Mediate the Association Between Sleep Duration and Incident Dementia Among Older Adults?
Sleep duration is a risk factor for multiple health outcomes. Growing attention has been directed to the association between sleep duration and dementia; however, results were inconsistent and the mechanisms remained largely unknown. We hypothesized that elevated levels of inflammation markers— C re...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7741554/ http://dx.doi.org/10.1093/geroni/igaa057.391 |
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author | Wu, Chenkai Xu, Weihao |
author_facet | Wu, Chenkai Xu, Weihao |
author_sort | Wu, Chenkai |
collection | PubMed |
description | Sleep duration is a risk factor for multiple health outcomes. Growing attention has been directed to the association between sleep duration and dementia; however, results were inconsistent and the mechanisms remained largely unknown. We hypothesized that elevated levels of inflammation markers— C reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α)—would mediate the association between sleep duration and dementia among older adults. Data were from the Health, Aging, and Body Composition Study; 3,010 participants free of dementia at baseline were included. Sleep duration was classified into: short (<6 hours), normal (6-8 hours), and long (>8 hours). Incident dementia was defined as (i) use of prescribed dementia medications, (ii) adjudicated dementia diagnosis, or (iii) a race-stratified cognitive decline >1.5 SDs from the baseline mean. We used Cox models to examine the associations among sleep duration, inflammation, and dementia. The average age was 73.6 years (SD=2.9); 49% were male and 41% were black. During 10 years of follow-up, 515 participants (17.1%) developed dementia. Long sleep duration was associated with higher hazard of dementia than normal sleep duration (HR=1.50, 95%CI=1.02-2.21). This association was attenuated by approximately 10% when CRP or IL-6 was added in the model. When all three inflammation markers were included in the model, the hazard ratio of long sleep duration was reduced by nearly 30% and no longer significant (HR=1.36, 95%CI=0.89-2.08). Long sleep duration was associated with high risk of incident dementia among older adults and the association was partly explained by elevated levels of inflammation markers. |
format | Online Article Text |
id | pubmed-7741554 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-77415542020-12-21 Does Inflammation Mediate the Association Between Sleep Duration and Incident Dementia Among Older Adults? Wu, Chenkai Xu, Weihao Innov Aging Abstracts Sleep duration is a risk factor for multiple health outcomes. Growing attention has been directed to the association between sleep duration and dementia; however, results were inconsistent and the mechanisms remained largely unknown. We hypothesized that elevated levels of inflammation markers— C reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α)—would mediate the association between sleep duration and dementia among older adults. Data were from the Health, Aging, and Body Composition Study; 3,010 participants free of dementia at baseline were included. Sleep duration was classified into: short (<6 hours), normal (6-8 hours), and long (>8 hours). Incident dementia was defined as (i) use of prescribed dementia medications, (ii) adjudicated dementia diagnosis, or (iii) a race-stratified cognitive decline >1.5 SDs from the baseline mean. We used Cox models to examine the associations among sleep duration, inflammation, and dementia. The average age was 73.6 years (SD=2.9); 49% were male and 41% were black. During 10 years of follow-up, 515 participants (17.1%) developed dementia. Long sleep duration was associated with higher hazard of dementia than normal sleep duration (HR=1.50, 95%CI=1.02-2.21). This association was attenuated by approximately 10% when CRP or IL-6 was added in the model. When all three inflammation markers were included in the model, the hazard ratio of long sleep duration was reduced by nearly 30% and no longer significant (HR=1.36, 95%CI=0.89-2.08). Long sleep duration was associated with high risk of incident dementia among older adults and the association was partly explained by elevated levels of inflammation markers. Oxford University Press 2020-12-16 /pmc/articles/PMC7741554/ http://dx.doi.org/10.1093/geroni/igaa057.391 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of The Gerontological Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Abstracts Wu, Chenkai Xu, Weihao Does Inflammation Mediate the Association Between Sleep Duration and Incident Dementia Among Older Adults? |
title | Does Inflammation Mediate the Association Between Sleep Duration and Incident Dementia Among Older Adults? |
title_full | Does Inflammation Mediate the Association Between Sleep Duration and Incident Dementia Among Older Adults? |
title_fullStr | Does Inflammation Mediate the Association Between Sleep Duration and Incident Dementia Among Older Adults? |
title_full_unstemmed | Does Inflammation Mediate the Association Between Sleep Duration and Incident Dementia Among Older Adults? |
title_short | Does Inflammation Mediate the Association Between Sleep Duration and Incident Dementia Among Older Adults? |
title_sort | does inflammation mediate the association between sleep duration and incident dementia among older adults? |
topic | Abstracts |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7741554/ http://dx.doi.org/10.1093/geroni/igaa057.391 |
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