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Does Inflammation Mediate the Association Between Sleep Duration and Incident Dementia Among Older Adults?

Sleep duration is a risk factor for multiple health outcomes. Growing attention has been directed to the association between sleep duration and dementia; however, results were inconsistent and the mechanisms remained largely unknown. We hypothesized that elevated levels of inflammation markers— C re...

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Autores principales: Wu, Chenkai, Xu, Weihao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7741554/
http://dx.doi.org/10.1093/geroni/igaa057.391
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author Wu, Chenkai
Xu, Weihao
author_facet Wu, Chenkai
Xu, Weihao
author_sort Wu, Chenkai
collection PubMed
description Sleep duration is a risk factor for multiple health outcomes. Growing attention has been directed to the association between sleep duration and dementia; however, results were inconsistent and the mechanisms remained largely unknown. We hypothesized that elevated levels of inflammation markers— C reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α)—would mediate the association between sleep duration and dementia among older adults. Data were from the Health, Aging, and Body Composition Study; 3,010 participants free of dementia at baseline were included. Sleep duration was classified into: short (<6 hours), normal (6-8 hours), and long (>8 hours). Incident dementia was defined as (i) use of prescribed dementia medications, (ii) adjudicated dementia diagnosis, or (iii) a race-stratified cognitive decline >1.5 SDs from the baseline mean. We used Cox models to examine the associations among sleep duration, inflammation, and dementia. The average age was 73.6 years (SD=2.9); 49% were male and 41% were black. During 10 years of follow-up, 515 participants (17.1%) developed dementia. Long sleep duration was associated with higher hazard of dementia than normal sleep duration (HR=1.50, 95%CI=1.02-2.21). This association was attenuated by approximately 10% when CRP or IL-6 was added in the model. When all three inflammation markers were included in the model, the hazard ratio of long sleep duration was reduced by nearly 30% and no longer significant (HR=1.36, 95%CI=0.89-2.08). Long sleep duration was associated with high risk of incident dementia among older adults and the association was partly explained by elevated levels of inflammation markers.
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spelling pubmed-77415542020-12-21 Does Inflammation Mediate the Association Between Sleep Duration and Incident Dementia Among Older Adults? Wu, Chenkai Xu, Weihao Innov Aging Abstracts Sleep duration is a risk factor for multiple health outcomes. Growing attention has been directed to the association between sleep duration and dementia; however, results were inconsistent and the mechanisms remained largely unknown. We hypothesized that elevated levels of inflammation markers— C reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α)—would mediate the association between sleep duration and dementia among older adults. Data were from the Health, Aging, and Body Composition Study; 3,010 participants free of dementia at baseline were included. Sleep duration was classified into: short (<6 hours), normal (6-8 hours), and long (>8 hours). Incident dementia was defined as (i) use of prescribed dementia medications, (ii) adjudicated dementia diagnosis, or (iii) a race-stratified cognitive decline >1.5 SDs from the baseline mean. We used Cox models to examine the associations among sleep duration, inflammation, and dementia. The average age was 73.6 years (SD=2.9); 49% were male and 41% were black. During 10 years of follow-up, 515 participants (17.1%) developed dementia. Long sleep duration was associated with higher hazard of dementia than normal sleep duration (HR=1.50, 95%CI=1.02-2.21). This association was attenuated by approximately 10% when CRP or IL-6 was added in the model. When all three inflammation markers were included in the model, the hazard ratio of long sleep duration was reduced by nearly 30% and no longer significant (HR=1.36, 95%CI=0.89-2.08). Long sleep duration was associated with high risk of incident dementia among older adults and the association was partly explained by elevated levels of inflammation markers. Oxford University Press 2020-12-16 /pmc/articles/PMC7741554/ http://dx.doi.org/10.1093/geroni/igaa057.391 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of The Gerontological Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstracts
Wu, Chenkai
Xu, Weihao
Does Inflammation Mediate the Association Between Sleep Duration and Incident Dementia Among Older Adults?
title Does Inflammation Mediate the Association Between Sleep Duration and Incident Dementia Among Older Adults?
title_full Does Inflammation Mediate the Association Between Sleep Duration and Incident Dementia Among Older Adults?
title_fullStr Does Inflammation Mediate the Association Between Sleep Duration and Incident Dementia Among Older Adults?
title_full_unstemmed Does Inflammation Mediate the Association Between Sleep Duration and Incident Dementia Among Older Adults?
title_short Does Inflammation Mediate the Association Between Sleep Duration and Incident Dementia Among Older Adults?
title_sort does inflammation mediate the association between sleep duration and incident dementia among older adults?
topic Abstracts
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7741554/
http://dx.doi.org/10.1093/geroni/igaa057.391
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