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Nutrient Intake Patterns Predict Homeostatic Dysregulation in an Older Quebec Population

The geometric framework for nutrition has largely been applied to macronutrients in experimental settings. Here, we utilize the framework to examine both macro and micronutrient intake patterns in observational human data. We used nutritional intake patterns (3x 24h recall per visit) of 1754 older Q...

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Autores principales: Cohen, Alan, Senior, Alistair, Legault, Véronique, Raubenheimer, David, Simpson, Stephen, Presse, Nancy, Gaudreau, Pierrette, Couteur, David Le
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7741555/
http://dx.doi.org/10.1093/geroni/igaa057.3101
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author Cohen, Alan
Senior, Alistair
Legault, Véronique
Raubenheimer, David
Simpson, Stephen
Presse, Nancy
Gaudreau, Pierrette
Couteur, David Le
author_facet Cohen, Alan
Senior, Alistair
Legault, Véronique
Raubenheimer, David
Simpson, Stephen
Presse, Nancy
Gaudreau, Pierrette
Couteur, David Le
author_sort Cohen, Alan
collection PubMed
description The geometric framework for nutrition has largely been applied to macronutrients in experimental settings. Here, we utilize the framework to examine both macro and micronutrient intake patterns in observational human data. We used nutritional intake patterns (3x 24h recall per visit) of 1754 older Quebecers from the NuAge cohort to predict multi-system homeostatic dysregulation scores calculated from 30 biomarkers. Intermediate intake of both macro- and micronutrients was generally associated with lower dysregulation scores (i.e., better health). Furthermore, there were often nutrient-nutrient interactions, such that the optimal level of one nutrient depends on the intake level of others. However, higher protein intake was generally associated with better health, and results varied substantially across different dysregulation systems. Accordingly, even though nutrition does have important effects on health trajectories during aging, it will be challenging to arrive at population-level recommendations to fine-tune nutrient intake patterns to optimize health beyond “everything in moderation.” Part of a symposium sponsored by the Nutrition Interest Group.
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spelling pubmed-77415552020-12-21 Nutrient Intake Patterns Predict Homeostatic Dysregulation in an Older Quebec Population Cohen, Alan Senior, Alistair Legault, Véronique Raubenheimer, David Simpson, Stephen Presse, Nancy Gaudreau, Pierrette Couteur, David Le Innov Aging Abstracts The geometric framework for nutrition has largely been applied to macronutrients in experimental settings. Here, we utilize the framework to examine both macro and micronutrient intake patterns in observational human data. We used nutritional intake patterns (3x 24h recall per visit) of 1754 older Quebecers from the NuAge cohort to predict multi-system homeostatic dysregulation scores calculated from 30 biomarkers. Intermediate intake of both macro- and micronutrients was generally associated with lower dysregulation scores (i.e., better health). Furthermore, there were often nutrient-nutrient interactions, such that the optimal level of one nutrient depends on the intake level of others. However, higher protein intake was generally associated with better health, and results varied substantially across different dysregulation systems. Accordingly, even though nutrition does have important effects on health trajectories during aging, it will be challenging to arrive at population-level recommendations to fine-tune nutrient intake patterns to optimize health beyond “everything in moderation.” Part of a symposium sponsored by the Nutrition Interest Group. Oxford University Press 2020-12-16 /pmc/articles/PMC7741555/ http://dx.doi.org/10.1093/geroni/igaa057.3101 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of The Gerontological Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstracts
Cohen, Alan
Senior, Alistair
Legault, Véronique
Raubenheimer, David
Simpson, Stephen
Presse, Nancy
Gaudreau, Pierrette
Couteur, David Le
Nutrient Intake Patterns Predict Homeostatic Dysregulation in an Older Quebec Population
title Nutrient Intake Patterns Predict Homeostatic Dysregulation in an Older Quebec Population
title_full Nutrient Intake Patterns Predict Homeostatic Dysregulation in an Older Quebec Population
title_fullStr Nutrient Intake Patterns Predict Homeostatic Dysregulation in an Older Quebec Population
title_full_unstemmed Nutrient Intake Patterns Predict Homeostatic Dysregulation in an Older Quebec Population
title_short Nutrient Intake Patterns Predict Homeostatic Dysregulation in an Older Quebec Population
title_sort nutrient intake patterns predict homeostatic dysregulation in an older quebec population
topic Abstracts
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7741555/
http://dx.doi.org/10.1093/geroni/igaa057.3101
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