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Associations Between a New Biomarker of Elevated Chronic Inflammation and Accelerated Aging
To further understand and measure the association between chronic inflammation, aging, and age-related diseases, broadly applicable standard biomarkers of systemic chronic inflammation are needed. We tested whether elevated blood levels of the emerging chronic inflammation marker soluble urokinase p...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7741594/ http://dx.doi.org/10.1093/geroni/igaa057.464 |
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author | Rasmussen, Line Caspi, Avshalom Moffitt, Terrie |
author_facet | Rasmussen, Line Caspi, Avshalom Moffitt, Terrie |
author_sort | Rasmussen, Line |
collection | PubMed |
description | To further understand and measure the association between chronic inflammation, aging, and age-related diseases, broadly applicable standard biomarkers of systemic chronic inflammation are needed. We tested whether elevated blood levels of the emerging chronic inflammation marker soluble urokinase plasminogen activator receptor (suPAR) were associated with accelerated aging, lower functional capacity, and cognitive decline. We used data from the population-representative longitudinal Dunedin Study (N=875). Plasma suPAR levels were analyzed at ages 38 and 45 years. We performed regression analyses adjusted for sex, smoking, and C-reactive protein. suPAR levels increased from 2.39 ng/mL (SD 0.89) at age 38 to 3.01 (SD 1.03) at age 45 years. Elevated suPAR was associated with accelerated pace of biological aging across multiple organ systems (β 0.28, 95% CI 0.21–0.35), older facial appearance (β 0.16, 95% CI 0.10–0.22), and with structural signs of older brain age (β 0.06, 95% CI -0.00–0.13). Moreover, participants with higher suPAR levels had lower functional capacity (more physical limitations [β 0.24, 95% CI 0.18–0.30]; slower gait speed [β -0.14, 95% CI -0.20; -0.08]) and greater decline in cognitive function (β -0.07, 95% CI -0.13; -0.01) from childhood to adulthood compared to those with lower suPAR levels. Finally, improvements in health habits between age 38 and 45 (smoking cessation or increased physical activity) were associated with less steep increases in suPAR levels over those years. Our findings provide initial support for the utility of suPAR in studying the role of chronic inflammation in accelerated aging and functional decline. |
format | Online Article Text |
id | pubmed-7741594 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-77415942020-12-21 Associations Between a New Biomarker of Elevated Chronic Inflammation and Accelerated Aging Rasmussen, Line Caspi, Avshalom Moffitt, Terrie Innov Aging Abstracts To further understand and measure the association between chronic inflammation, aging, and age-related diseases, broadly applicable standard biomarkers of systemic chronic inflammation are needed. We tested whether elevated blood levels of the emerging chronic inflammation marker soluble urokinase plasminogen activator receptor (suPAR) were associated with accelerated aging, lower functional capacity, and cognitive decline. We used data from the population-representative longitudinal Dunedin Study (N=875). Plasma suPAR levels were analyzed at ages 38 and 45 years. We performed regression analyses adjusted for sex, smoking, and C-reactive protein. suPAR levels increased from 2.39 ng/mL (SD 0.89) at age 38 to 3.01 (SD 1.03) at age 45 years. Elevated suPAR was associated with accelerated pace of biological aging across multiple organ systems (β 0.28, 95% CI 0.21–0.35), older facial appearance (β 0.16, 95% CI 0.10–0.22), and with structural signs of older brain age (β 0.06, 95% CI -0.00–0.13). Moreover, participants with higher suPAR levels had lower functional capacity (more physical limitations [β 0.24, 95% CI 0.18–0.30]; slower gait speed [β -0.14, 95% CI -0.20; -0.08]) and greater decline in cognitive function (β -0.07, 95% CI -0.13; -0.01) from childhood to adulthood compared to those with lower suPAR levels. Finally, improvements in health habits between age 38 and 45 (smoking cessation or increased physical activity) were associated with less steep increases in suPAR levels over those years. Our findings provide initial support for the utility of suPAR in studying the role of chronic inflammation in accelerated aging and functional decline. Oxford University Press 2020-12-16 /pmc/articles/PMC7741594/ http://dx.doi.org/10.1093/geroni/igaa057.464 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of The Gerontological Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Abstracts Rasmussen, Line Caspi, Avshalom Moffitt, Terrie Associations Between a New Biomarker of Elevated Chronic Inflammation and Accelerated Aging |
title | Associations Between a New Biomarker of Elevated Chronic Inflammation and Accelerated Aging |
title_full | Associations Between a New Biomarker of Elevated Chronic Inflammation and Accelerated Aging |
title_fullStr | Associations Between a New Biomarker of Elevated Chronic Inflammation and Accelerated Aging |
title_full_unstemmed | Associations Between a New Biomarker of Elevated Chronic Inflammation and Accelerated Aging |
title_short | Associations Between a New Biomarker of Elevated Chronic Inflammation and Accelerated Aging |
title_sort | associations between a new biomarker of elevated chronic inflammation and accelerated aging |
topic | Abstracts |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7741594/ http://dx.doi.org/10.1093/geroni/igaa057.464 |
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