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Associations Between a New Biomarker of Elevated Chronic Inflammation and Accelerated Aging

To further understand and measure the association between chronic inflammation, aging, and age-related diseases, broadly applicable standard biomarkers of systemic chronic inflammation are needed. We tested whether elevated blood levels of the emerging chronic inflammation marker soluble urokinase p...

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Autores principales: Rasmussen, Line, Caspi, Avshalom, Moffitt, Terrie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7741594/
http://dx.doi.org/10.1093/geroni/igaa057.464
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author Rasmussen, Line
Caspi, Avshalom
Moffitt, Terrie
author_facet Rasmussen, Line
Caspi, Avshalom
Moffitt, Terrie
author_sort Rasmussen, Line
collection PubMed
description To further understand and measure the association between chronic inflammation, aging, and age-related diseases, broadly applicable standard biomarkers of systemic chronic inflammation are needed. We tested whether elevated blood levels of the emerging chronic inflammation marker soluble urokinase plasminogen activator receptor (suPAR) were associated with accelerated aging, lower functional capacity, and cognitive decline. We used data from the population-representative longitudinal Dunedin Study (N=875). Plasma suPAR levels were analyzed at ages 38 and 45 years. We performed regression analyses adjusted for sex, smoking, and C-reactive protein. suPAR levels increased from 2.39 ng/mL (SD 0.89) at age 38 to 3.01 (SD 1.03) at age 45 years. Elevated suPAR was associated with accelerated pace of biological aging across multiple organ systems (β 0.28, 95% CI 0.21–0.35), older facial appearance (β 0.16, 95% CI 0.10–0.22), and with structural signs of older brain age (β 0.06, 95% CI -0.00–0.13). Moreover, participants with higher suPAR levels had lower functional capacity (more physical limitations [β 0.24, 95% CI 0.18–0.30]; slower gait speed [β -0.14, 95% CI -0.20; -0.08]) and greater decline in cognitive function (β -0.07, 95% CI -0.13; -0.01) from childhood to adulthood compared to those with lower suPAR levels. Finally, improvements in health habits between age 38 and 45 (smoking cessation or increased physical activity) were associated with less steep increases in suPAR levels over those years. Our findings provide initial support for the utility of suPAR in studying the role of chronic inflammation in accelerated aging and functional decline.
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spelling pubmed-77415942020-12-21 Associations Between a New Biomarker of Elevated Chronic Inflammation and Accelerated Aging Rasmussen, Line Caspi, Avshalom Moffitt, Terrie Innov Aging Abstracts To further understand and measure the association between chronic inflammation, aging, and age-related diseases, broadly applicable standard biomarkers of systemic chronic inflammation are needed. We tested whether elevated blood levels of the emerging chronic inflammation marker soluble urokinase plasminogen activator receptor (suPAR) were associated with accelerated aging, lower functional capacity, and cognitive decline. We used data from the population-representative longitudinal Dunedin Study (N=875). Plasma suPAR levels were analyzed at ages 38 and 45 years. We performed regression analyses adjusted for sex, smoking, and C-reactive protein. suPAR levels increased from 2.39 ng/mL (SD 0.89) at age 38 to 3.01 (SD 1.03) at age 45 years. Elevated suPAR was associated with accelerated pace of biological aging across multiple organ systems (β 0.28, 95% CI 0.21–0.35), older facial appearance (β 0.16, 95% CI 0.10–0.22), and with structural signs of older brain age (β 0.06, 95% CI -0.00–0.13). Moreover, participants with higher suPAR levels had lower functional capacity (more physical limitations [β 0.24, 95% CI 0.18–0.30]; slower gait speed [β -0.14, 95% CI -0.20; -0.08]) and greater decline in cognitive function (β -0.07, 95% CI -0.13; -0.01) from childhood to adulthood compared to those with lower suPAR levels. Finally, improvements in health habits between age 38 and 45 (smoking cessation or increased physical activity) were associated with less steep increases in suPAR levels over those years. Our findings provide initial support for the utility of suPAR in studying the role of chronic inflammation in accelerated aging and functional decline. Oxford University Press 2020-12-16 /pmc/articles/PMC7741594/ http://dx.doi.org/10.1093/geroni/igaa057.464 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of The Gerontological Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstracts
Rasmussen, Line
Caspi, Avshalom
Moffitt, Terrie
Associations Between a New Biomarker of Elevated Chronic Inflammation and Accelerated Aging
title Associations Between a New Biomarker of Elevated Chronic Inflammation and Accelerated Aging
title_full Associations Between a New Biomarker of Elevated Chronic Inflammation and Accelerated Aging
title_fullStr Associations Between a New Biomarker of Elevated Chronic Inflammation and Accelerated Aging
title_full_unstemmed Associations Between a New Biomarker of Elevated Chronic Inflammation and Accelerated Aging
title_short Associations Between a New Biomarker of Elevated Chronic Inflammation and Accelerated Aging
title_sort associations between a new biomarker of elevated chronic inflammation and accelerated aging
topic Abstracts
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7741594/
http://dx.doi.org/10.1093/geroni/igaa057.464
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