Cargando…

Detection of Alzheimer’s Disease-Related Cognitive Change With the Mobile Cognitive App Performance Platform

This study investigates the psychometric properties of the mobile cognitive app performance platform (mCAPP), designed to detect memory changes associated with preclinical Alzheimer’s Disease (AD). The mCAPP memory task includes learning and matching hidden card pairs and incorporates increasing mem...

Descripción completa

Detalles Bibliográficos
Autores principales: Mechanic-Hamilton, Dawn, Lydon, Sean, Miller, Alexander, Halberstadter, Kimberly, Lane, Jacqueline, Das, Sandhitsu, Wolk, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7742316/
http://dx.doi.org/10.1093/geroni/igaa057.2907
_version_ 1783623959669899264
author Mechanic-Hamilton, Dawn
Lydon, Sean
Miller, Alexander
Halberstadter, Kimberly
Lane, Jacqueline
Das, Sandhitsu
Wolk, David
author_facet Mechanic-Hamilton, Dawn
Lydon, Sean
Miller, Alexander
Halberstadter, Kimberly
Lane, Jacqueline
Das, Sandhitsu
Wolk, David
author_sort Mechanic-Hamilton, Dawn
collection PubMed
description This study investigates the psychometric properties of the mobile cognitive app performance platform (mCAPP), designed to detect memory changes associated with preclinical Alzheimer’s Disease (AD). The mCAPP memory task includes learning and matching hidden card pairs and incorporates increasing memory load, pattern separation features, and spatial memory. Participants included 30 older adults with normal cognition. They completed the mCAPP, paper and pencil neuropsychological tests and a subset completed a high-resolution structural MRI. The majority of participants found the difficulty level of the mCAPP game to be “just right”. Accuracy on the mCAPP correlated with performance on memory and executive measures, while speed of performance on the mCAPP correlated with performance on attention and executive function measures. Longer trial duration correlated with measures of the parahippocampal cortex. The relationship of mCAPP variables with molecular biomarkers, at-home and burst testing, and development of additional cognitive measures will also be discussed.
format Online
Article
Text
id pubmed-7742316
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-77423162020-12-21 Detection of Alzheimer’s Disease-Related Cognitive Change With the Mobile Cognitive App Performance Platform Mechanic-Hamilton, Dawn Lydon, Sean Miller, Alexander Halberstadter, Kimberly Lane, Jacqueline Das, Sandhitsu Wolk, David Innov Aging Abstracts This study investigates the psychometric properties of the mobile cognitive app performance platform (mCAPP), designed to detect memory changes associated with preclinical Alzheimer’s Disease (AD). The mCAPP memory task includes learning and matching hidden card pairs and incorporates increasing memory load, pattern separation features, and spatial memory. Participants included 30 older adults with normal cognition. They completed the mCAPP, paper and pencil neuropsychological tests and a subset completed a high-resolution structural MRI. The majority of participants found the difficulty level of the mCAPP game to be “just right”. Accuracy on the mCAPP correlated with performance on memory and executive measures, while speed of performance on the mCAPP correlated with performance on attention and executive function measures. Longer trial duration correlated with measures of the parahippocampal cortex. The relationship of mCAPP variables with molecular biomarkers, at-home and burst testing, and development of additional cognitive measures will also be discussed. Oxford University Press 2020-12-16 /pmc/articles/PMC7742316/ http://dx.doi.org/10.1093/geroni/igaa057.2907 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of The Gerontological Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstracts
Mechanic-Hamilton, Dawn
Lydon, Sean
Miller, Alexander
Halberstadter, Kimberly
Lane, Jacqueline
Das, Sandhitsu
Wolk, David
Detection of Alzheimer’s Disease-Related Cognitive Change With the Mobile Cognitive App Performance Platform
title Detection of Alzheimer’s Disease-Related Cognitive Change With the Mobile Cognitive App Performance Platform
title_full Detection of Alzheimer’s Disease-Related Cognitive Change With the Mobile Cognitive App Performance Platform
title_fullStr Detection of Alzheimer’s Disease-Related Cognitive Change With the Mobile Cognitive App Performance Platform
title_full_unstemmed Detection of Alzheimer’s Disease-Related Cognitive Change With the Mobile Cognitive App Performance Platform
title_short Detection of Alzheimer’s Disease-Related Cognitive Change With the Mobile Cognitive App Performance Platform
title_sort detection of alzheimer’s disease-related cognitive change with the mobile cognitive app performance platform
topic Abstracts
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7742316/
http://dx.doi.org/10.1093/geroni/igaa057.2907
work_keys_str_mv AT mechanichamiltondawn detectionofalzheimersdiseaserelatedcognitivechangewiththemobilecognitiveappperformanceplatform
AT lydonsean detectionofalzheimersdiseaserelatedcognitivechangewiththemobilecognitiveappperformanceplatform
AT milleralexander detectionofalzheimersdiseaserelatedcognitivechangewiththemobilecognitiveappperformanceplatform
AT halberstadterkimberly detectionofalzheimersdiseaserelatedcognitivechangewiththemobilecognitiveappperformanceplatform
AT lanejacqueline detectionofalzheimersdiseaserelatedcognitivechangewiththemobilecognitiveappperformanceplatform
AT dassandhitsu detectionofalzheimersdiseaserelatedcognitivechangewiththemobilecognitiveappperformanceplatform
AT wolkdavid detectionofalzheimersdiseaserelatedcognitivechangewiththemobilecognitiveappperformanceplatform