Prrx1 Fibroblasts Represent a Pro-fibrotic Lineage in the Mouse Ventral Dermis

Fibroblast heterogeneity has been shown within the unwounded mouse dorsal dermis, with fibroblast subpopulations being identified according to anatomical location and embryonic lineage. Using lineage tracing, we demonstrate that paired related homeobox 1 (Prrx1)-expressing fibroblasts are responsibl...

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Detalles Bibliográficos
Autores principales: Leavitt, Tripp, Hu, Michael S., Borrelli, Mimi R., Januszyk, Michael, Garcia, Julia T., Ransom, Ryan C., Mascharak, Shamik, desJardins-Park, Heather E., Litzenburger, Ulrike M., Walmsley, Graham G., Marshall, Clement D., Moore, Alessandra L., Duoto, Bryan, Adem, Sandeep, Foster, Deshka S., Salhotra, Ankit, Shen, Abra H., Griffin, Michelle, Shen, Ethan Z., Barnes, Leandra A., Zielins, Elizabeth R., Maan, Zeshaan N., Wei, Yuning, Chan, Charles K.F., Wan, Derrick C., Lorenz, Hermann P., Chang, Howard Y., Gurtner, Geoffrey C., Longaker, Michael T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7742512/
https://www.ncbi.nlm.nih.gov/pubmed/33176144
http://dx.doi.org/10.1016/j.celrep.2020.108356
Descripción
Sumario:Fibroblast heterogeneity has been shown within the unwounded mouse dorsal dermis, with fibroblast subpopulations being identified according to anatomical location and embryonic lineage. Using lineage tracing, we demonstrate that paired related homeobox 1 (Prrx1)-expressing fibroblasts are responsible for acute and chronic fibroses in the ventral dermis. Single-cell transcriptomics further corroborated the inherent fibrotic characteristics of Prrx1 fibroblasts during wound repair. In summary, we identify and characterize a fibroblast subpopulation in the mouse ventral dermis with intrinsic scar-forming potential.

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