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Prrx1 Fibroblasts Represent a Pro-fibrotic Lineage in the Mouse Ventral Dermis
Fibroblast heterogeneity has been shown within the unwounded mouse dorsal dermis, with fibroblast subpopulations being identified according to anatomical location and embryonic lineage. Using lineage tracing, we demonstrate that paired related homeobox 1 (Prrx1)-expressing fibroblasts are responsibl...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7742512/ https://www.ncbi.nlm.nih.gov/pubmed/33176144 http://dx.doi.org/10.1016/j.celrep.2020.108356 |
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| author | Leavitt, Tripp Hu, Michael S. Borrelli, Mimi R. Januszyk, Michael Garcia, Julia T. Ransom, Ryan C. Mascharak, Shamik desJardins-Park, Heather E. Litzenburger, Ulrike M. Walmsley, Graham G. Marshall, Clement D. Moore, Alessandra L. Duoto, Bryan Adem, Sandeep Foster, Deshka S. Salhotra, Ankit Shen, Abra H. Griffin, Michelle Shen, Ethan Z. Barnes, Leandra A. Zielins, Elizabeth R. Maan, Zeshaan N. Wei, Yuning Chan, Charles K.F. Wan, Derrick C. Lorenz, Hermann P. Chang, Howard Y. Gurtner, Geoffrey C. Longaker, Michael T. |
| author_facet | Leavitt, Tripp Hu, Michael S. Borrelli, Mimi R. Januszyk, Michael Garcia, Julia T. Ransom, Ryan C. Mascharak, Shamik desJardins-Park, Heather E. Litzenburger, Ulrike M. Walmsley, Graham G. Marshall, Clement D. Moore, Alessandra L. Duoto, Bryan Adem, Sandeep Foster, Deshka S. Salhotra, Ankit Shen, Abra H. Griffin, Michelle Shen, Ethan Z. Barnes, Leandra A. Zielins, Elizabeth R. Maan, Zeshaan N. Wei, Yuning Chan, Charles K.F. Wan, Derrick C. Lorenz, Hermann P. Chang, Howard Y. Gurtner, Geoffrey C. Longaker, Michael T. |
| author_sort | Leavitt, Tripp |
| collection | PubMed |
| description | Fibroblast heterogeneity has been shown within the unwounded mouse dorsal dermis, with fibroblast subpopulations being identified according to anatomical location and embryonic lineage. Using lineage tracing, we demonstrate that paired related homeobox 1 (Prrx1)-expressing fibroblasts are responsible for acute and chronic fibroses in the ventral dermis. Single-cell transcriptomics further corroborated the inherent fibrotic characteristics of Prrx1 fibroblasts during wound repair. In summary, we identify and characterize a fibroblast subpopulation in the mouse ventral dermis with intrinsic scar-forming potential. |
| format | Online Article Text |
| id | pubmed-7742512 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-77425122020-12-16 Prrx1 Fibroblasts Represent a Pro-fibrotic Lineage in the Mouse Ventral Dermis Leavitt, Tripp Hu, Michael S. Borrelli, Mimi R. Januszyk, Michael Garcia, Julia T. Ransom, Ryan C. Mascharak, Shamik desJardins-Park, Heather E. Litzenburger, Ulrike M. Walmsley, Graham G. Marshall, Clement D. Moore, Alessandra L. Duoto, Bryan Adem, Sandeep Foster, Deshka S. Salhotra, Ankit Shen, Abra H. Griffin, Michelle Shen, Ethan Z. Barnes, Leandra A. Zielins, Elizabeth R. Maan, Zeshaan N. Wei, Yuning Chan, Charles K.F. Wan, Derrick C. Lorenz, Hermann P. Chang, Howard Y. Gurtner, Geoffrey C. Longaker, Michael T. Cell Rep Article Fibroblast heterogeneity has been shown within the unwounded mouse dorsal dermis, with fibroblast subpopulations being identified according to anatomical location and embryonic lineage. Using lineage tracing, we demonstrate that paired related homeobox 1 (Prrx1)-expressing fibroblasts are responsible for acute and chronic fibroses in the ventral dermis. Single-cell transcriptomics further corroborated the inherent fibrotic characteristics of Prrx1 fibroblasts during wound repair. In summary, we identify and characterize a fibroblast subpopulation in the mouse ventral dermis with intrinsic scar-forming potential. 2020-11-10 /pmc/articles/PMC7742512/ /pubmed/33176144 http://dx.doi.org/10.1016/j.celrep.2020.108356 Text en This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| spellingShingle | Article Leavitt, Tripp Hu, Michael S. Borrelli, Mimi R. Januszyk, Michael Garcia, Julia T. Ransom, Ryan C. Mascharak, Shamik desJardins-Park, Heather E. Litzenburger, Ulrike M. Walmsley, Graham G. Marshall, Clement D. Moore, Alessandra L. Duoto, Bryan Adem, Sandeep Foster, Deshka S. Salhotra, Ankit Shen, Abra H. Griffin, Michelle Shen, Ethan Z. Barnes, Leandra A. Zielins, Elizabeth R. Maan, Zeshaan N. Wei, Yuning Chan, Charles K.F. Wan, Derrick C. Lorenz, Hermann P. Chang, Howard Y. Gurtner, Geoffrey C. Longaker, Michael T. Prrx1 Fibroblasts Represent a Pro-fibrotic Lineage in the Mouse Ventral Dermis |
| title | Prrx1 Fibroblasts Represent a Pro-fibrotic Lineage in the Mouse Ventral Dermis |
| title_full | Prrx1 Fibroblasts Represent a Pro-fibrotic Lineage in the Mouse Ventral Dermis |
| title_fullStr | Prrx1 Fibroblasts Represent a Pro-fibrotic Lineage in the Mouse Ventral Dermis |
| title_full_unstemmed | Prrx1 Fibroblasts Represent a Pro-fibrotic Lineage in the Mouse Ventral Dermis |
| title_short | Prrx1 Fibroblasts Represent a Pro-fibrotic Lineage in the Mouse Ventral Dermis |
| title_sort | prrx1 fibroblasts represent a pro-fibrotic lineage in the mouse ventral dermis |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7742512/ https://www.ncbi.nlm.nih.gov/pubmed/33176144 http://dx.doi.org/10.1016/j.celrep.2020.108356 |
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