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Microbiome-Mitochondria Communication in the Regulation of Host Longevity
Mitochondria are ancient relatives of bacteria in eukaryotic cells and dynamically interconnected through organelle fusion and fission. Given the close relationship between bacteria and eukaryotic mitochondria during evolution, my group is interested in understanding the critical role of their commu...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Oxford University Press
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7742518/ http://dx.doi.org/10.1093/geroni/igaa057.2637 |
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author | Wang, Meng |
author_facet | Wang, Meng |
author_sort | Wang, Meng |
collection | PubMed |
description | Mitochondria are ancient relatives of bacteria in eukaryotic cells and dynamically interconnected through organelle fusion and fission. Given the close relationship between bacteria and eukaryotic mitochondria during evolution, my group is interested in understanding the critical role of their communication in regulating host’s longevity. We have conducted genome-scale screens to decipher how bacterial genetic composition impacts host longevity, leading to the discovery of specific bacteria-secreted metabolites that fine-tune the mitochondrial fusion-fission balance and consequently promotes longevity across different host species. We have further developed optogenetic approaches to manipulate bacterial gene expression and metabolite production inside the gut of live organisms, in order to investigate the microbiome-mitochondria communication in time and space. Our studies demonstrate a novel mode of signaling communication between bacteria and mitochondria, reveal its vital impacts on host healthy aging, and provide new methods to decipher the spatiotemporal relationship between the microbiome and the host. |
format | Online Article Text |
id | pubmed-7742518 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-77425182020-12-21 Microbiome-Mitochondria Communication in the Regulation of Host Longevity Wang, Meng Innov Aging Abstracts Mitochondria are ancient relatives of bacteria in eukaryotic cells and dynamically interconnected through organelle fusion and fission. Given the close relationship between bacteria and eukaryotic mitochondria during evolution, my group is interested in understanding the critical role of their communication in regulating host’s longevity. We have conducted genome-scale screens to decipher how bacterial genetic composition impacts host longevity, leading to the discovery of specific bacteria-secreted metabolites that fine-tune the mitochondrial fusion-fission balance and consequently promotes longevity across different host species. We have further developed optogenetic approaches to manipulate bacterial gene expression and metabolite production inside the gut of live organisms, in order to investigate the microbiome-mitochondria communication in time and space. Our studies demonstrate a novel mode of signaling communication between bacteria and mitochondria, reveal its vital impacts on host healthy aging, and provide new methods to decipher the spatiotemporal relationship between the microbiome and the host. Oxford University Press 2020-12-16 /pmc/articles/PMC7742518/ http://dx.doi.org/10.1093/geroni/igaa057.2637 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of The Gerontological Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Abstracts Wang, Meng Microbiome-Mitochondria Communication in the Regulation of Host Longevity |
title | Microbiome-Mitochondria Communication in the Regulation of Host Longevity |
title_full | Microbiome-Mitochondria Communication in the Regulation of Host Longevity |
title_fullStr | Microbiome-Mitochondria Communication in the Regulation of Host Longevity |
title_full_unstemmed | Microbiome-Mitochondria Communication in the Regulation of Host Longevity |
title_short | Microbiome-Mitochondria Communication in the Regulation of Host Longevity |
title_sort | microbiome-mitochondria communication in the regulation of host longevity |
topic | Abstracts |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7742518/ http://dx.doi.org/10.1093/geroni/igaa057.2637 |
work_keys_str_mv | AT wangmeng microbiomemitochondriacommunicationintheregulationofhostlongevity |