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Greater Perceived Physical Fatigability Is Associated with Lower Cognition: The Long Life Family Study

Greater perceived physical fatigability is associated with physical functional decline, but few studies have examined its relation with cognition. Adults ≥60 (mean±SD age 73.7±10.5, 54.7% female, 99.6% white) from the Long Life Family Study (n=2355) completed the Pittsburgh Fatigability Scale (PFS,...

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Autores principales: Gmelin, Theresa, Rosso, Andrea, Andersen, Stacy, Cosentino, Stephanie, Wojczynski, Mary, Christensen, Kaare, Boudreau, Robert, Glynn, Nancy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7742523/
http://dx.doi.org/10.1093/geroni/igaa057.2831
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author Gmelin, Theresa
Rosso, Andrea
Andersen, Stacy
Cosentino, Stephanie
Wojczynski, Mary
Christensen, Kaare
Boudreau, Robert
Glynn, Nancy
author_facet Gmelin, Theresa
Rosso, Andrea
Andersen, Stacy
Cosentino, Stephanie
Wojczynski, Mary
Christensen, Kaare
Boudreau, Robert
Glynn, Nancy
author_sort Gmelin, Theresa
collection PubMed
description Greater perceived physical fatigability is associated with physical functional decline, but few studies have examined its relation with cognition. Adults ≥60 (mean±SD age 73.7±10.5, 54.7% female, 99.6% white) from the Long Life Family Study (n=2355) completed the Pittsburgh Fatigability Scale (PFS, 0-50, higher=greater fatigability) and a neurocognitive examination. Generalized estimating equations were used to account for family structure. Covariates included age, sex, field center, depressive symptoms (Center for Epidemiological Studies-Depression), education, and self-reported health. Each 1-point greater PFS was associated with lower: (1) global cognition (Mini-Mental Status Exam; β=-0.36,p<.0001), (2) verbal fluency (phonemic: β=-0.09,p=.029 and semantic: β=-0.14,p<.0001), (3) memory (Hopkins Verbal Learning Test-Revised: β=-0.06,p=.037), and (4) psychomotor speed (Digit Symbol Substitution Test: β=-0.10,p<.0001), after covariate adjustment. Greater perceived physical fatigability was significantly associated with lower memory and cognitive function in older adults, and may represent a promising new biomarker of biological aging reflecting declining brain reserve, resilience, and neurodegeneration.
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spelling pubmed-77425232020-12-21 Greater Perceived Physical Fatigability Is Associated with Lower Cognition: The Long Life Family Study Gmelin, Theresa Rosso, Andrea Andersen, Stacy Cosentino, Stephanie Wojczynski, Mary Christensen, Kaare Boudreau, Robert Glynn, Nancy Innov Aging Abstracts Greater perceived physical fatigability is associated with physical functional decline, but few studies have examined its relation with cognition. Adults ≥60 (mean±SD age 73.7±10.5, 54.7% female, 99.6% white) from the Long Life Family Study (n=2355) completed the Pittsburgh Fatigability Scale (PFS, 0-50, higher=greater fatigability) and a neurocognitive examination. Generalized estimating equations were used to account for family structure. Covariates included age, sex, field center, depressive symptoms (Center for Epidemiological Studies-Depression), education, and self-reported health. Each 1-point greater PFS was associated with lower: (1) global cognition (Mini-Mental Status Exam; β=-0.36,p<.0001), (2) verbal fluency (phonemic: β=-0.09,p=.029 and semantic: β=-0.14,p<.0001), (3) memory (Hopkins Verbal Learning Test-Revised: β=-0.06,p=.037), and (4) psychomotor speed (Digit Symbol Substitution Test: β=-0.10,p<.0001), after covariate adjustment. Greater perceived physical fatigability was significantly associated with lower memory and cognitive function in older adults, and may represent a promising new biomarker of biological aging reflecting declining brain reserve, resilience, and neurodegeneration. Oxford University Press 2020-12-16 /pmc/articles/PMC7742523/ http://dx.doi.org/10.1093/geroni/igaa057.2831 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of The Gerontological Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstracts
Gmelin, Theresa
Rosso, Andrea
Andersen, Stacy
Cosentino, Stephanie
Wojczynski, Mary
Christensen, Kaare
Boudreau, Robert
Glynn, Nancy
Greater Perceived Physical Fatigability Is Associated with Lower Cognition: The Long Life Family Study
title Greater Perceived Physical Fatigability Is Associated with Lower Cognition: The Long Life Family Study
title_full Greater Perceived Physical Fatigability Is Associated with Lower Cognition: The Long Life Family Study
title_fullStr Greater Perceived Physical Fatigability Is Associated with Lower Cognition: The Long Life Family Study
title_full_unstemmed Greater Perceived Physical Fatigability Is Associated with Lower Cognition: The Long Life Family Study
title_short Greater Perceived Physical Fatigability Is Associated with Lower Cognition: The Long Life Family Study
title_sort greater perceived physical fatigability is associated with lower cognition: the long life family study
topic Abstracts
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7742523/
http://dx.doi.org/10.1093/geroni/igaa057.2831
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