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Mechanisms of Lifespan Extension by Sirt6 in Drosophila melanogaster
Sirt6 is a multifunctional enzyme that regulates numerous cellular processes connected to longevity. Overexpressing Sirt6 extends lifespan in mice, but the underlying cellular mechanisms are unclear. Here, we used the powerful genetic tools and short lifespan of Drosophila melanogaster to better und...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7742554/ http://dx.doi.org/10.1093/geroni/igaa057.2617 |
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author | Taylor, Jackson Wood, Jason Finn, Matthew Liu, Julianna Mizerak, Evan Gordon, Sarah Hutfilz, Corinne Helfand, Stephen |
author_facet | Taylor, Jackson Wood, Jason Finn, Matthew Liu, Julianna Mizerak, Evan Gordon, Sarah Hutfilz, Corinne Helfand, Stephen |
author_sort | Taylor, Jackson |
collection | PubMed |
description | Sirt6 is a multifunctional enzyme that regulates numerous cellular processes connected to longevity. Overexpressing Sirt6 extends lifespan in mice, but the underlying cellular mechanisms are unclear. Here, we used the powerful genetic tools and short lifespan of Drosophila melanogaster to better understand the precise mechanisms by which Sirt6 regulates longevity. Sirt6 OE in flies produces robust extension of median lifespan in both sexes. Molecular and biochemical analyses reveal that Sirt6 OE reduces expression of genes involved in protein synthesis, including many Myc target genes, via epigenetic regulation. We will further discuss our findings on the connection between Sirt6, Myc, and the molecular regulation of protein synthesis and lifespan, as well as additional Sirt6 longevity mechanisms we identified, including autophagy and silencing of transposable elements. |
format | Online Article Text |
id | pubmed-7742554 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-77425542020-12-21 Mechanisms of Lifespan Extension by Sirt6 in Drosophila melanogaster Taylor, Jackson Wood, Jason Finn, Matthew Liu, Julianna Mizerak, Evan Gordon, Sarah Hutfilz, Corinne Helfand, Stephen Innov Aging Abstracts Sirt6 is a multifunctional enzyme that regulates numerous cellular processes connected to longevity. Overexpressing Sirt6 extends lifespan in mice, but the underlying cellular mechanisms are unclear. Here, we used the powerful genetic tools and short lifespan of Drosophila melanogaster to better understand the precise mechanisms by which Sirt6 regulates longevity. Sirt6 OE in flies produces robust extension of median lifespan in both sexes. Molecular and biochemical analyses reveal that Sirt6 OE reduces expression of genes involved in protein synthesis, including many Myc target genes, via epigenetic regulation. We will further discuss our findings on the connection between Sirt6, Myc, and the molecular regulation of protein synthesis and lifespan, as well as additional Sirt6 longevity mechanisms we identified, including autophagy and silencing of transposable elements. Oxford University Press 2020-12-16 /pmc/articles/PMC7742554/ http://dx.doi.org/10.1093/geroni/igaa057.2617 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of The Gerontological Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Abstracts Taylor, Jackson Wood, Jason Finn, Matthew Liu, Julianna Mizerak, Evan Gordon, Sarah Hutfilz, Corinne Helfand, Stephen Mechanisms of Lifespan Extension by Sirt6 in Drosophila melanogaster |
title | Mechanisms of Lifespan Extension by Sirt6 in Drosophila melanogaster |
title_full | Mechanisms of Lifespan Extension by Sirt6 in Drosophila melanogaster |
title_fullStr | Mechanisms of Lifespan Extension by Sirt6 in Drosophila melanogaster |
title_full_unstemmed | Mechanisms of Lifespan Extension by Sirt6 in Drosophila melanogaster |
title_short | Mechanisms of Lifespan Extension by Sirt6 in Drosophila melanogaster |
title_sort | mechanisms of lifespan extension by sirt6 in drosophila melanogaster |
topic | Abstracts |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7742554/ http://dx.doi.org/10.1093/geroni/igaa057.2617 |
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