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A Mutation Upstream of the rplN-rpsD Ribosomal Operon Downregulates Bordetella pertussis Virulence Factor Production without Compromising Bacterial Survival within Human Macrophages

The BvgS/BvgA two-component system controls expression of ∼550 genes of Bordetella pertussis, of which, ∼245 virulence-related genes are positively regulated by the BvgS-phosphorylated transcriptional regulator protein BvgA (BvgA∼P). We found that a single G-to-T nucleotide transversion in the 5′-un...

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Detalles Bibliográficos
Autores principales:	Novák, Jakub, Jurnečka, David, Linhartová, Irena, Holubová, Jana, Staněk, Ondřej, Štipl, Daniel, Dienstbier, Ana, Večerek, Branislav, Azevedo, Nayara, Provazník, Jan, Beneš, Vladimír, Šebo, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7742992/ https://www.ncbi.nlm.nih.gov/pubmed/33293402 http://dx.doi.org/10.1128/mSystems.00612-20

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