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AVPR1A and Stress in Adults With Sickle Cell Disease–Related Chronic Pain
Purpose: Emotional stress is a known pain trigger in patients with sickle cell disease (SCD). The Arginine vasopressin receptor 1A gene (AVPR1A), SNP rs10877969, is associated with acute pain and stress-related pain. Our study investigated the association between AVPR1A genotype with stress and age...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7742995/ http://dx.doi.org/10.1093/geroni/igaa057.2843 |
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author | Roach, Keesha Dyal, Brenda Chamala, Srikar Yao, Yingwei Fillingim, Roger Wang, Zajie Molokie, Robert Wilkie, Diana |
author_facet | Roach, Keesha Dyal, Brenda Chamala, Srikar Yao, Yingwei Fillingim, Roger Wang, Zajie Molokie, Robert Wilkie, Diana |
author_sort | Roach, Keesha |
collection | PubMed |
description | Purpose: Emotional stress is a known pain trigger in patients with sickle cell disease (SCD). The Arginine vasopressin receptor 1A gene (AVPR1A), SNP rs10877969, is associated with acute pain and stress-related pain. Our study investigated the association between AVPR1A genotype with stress and age in adults with SCD pain. Methods: 169 participants with SCD and chronic pain (100% African descent; mean age 36.4 ± 11.6 years [range =18-74 years]) completed the Perceived Stress Questionnaire. The SNP was evaluated as the imputed score was R2>0.8. ANOVA compared stress by genotype and age. Findings: Mean stress scores were significantly lower (p<0.05) for the older adults (0.35 ± 0.18) than the younger adults (0.41 ± 0.17). Mean stress scores were not significantly different by genotype for younger or older adults. Discussion: The rs10877969 genotype frequency was not different by age. In contrast to prior research, there was no association between genotype and stress. |
format | Online Article Text |
id | pubmed-7742995 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-77429952020-12-21 AVPR1A and Stress in Adults With Sickle Cell Disease–Related Chronic Pain Roach, Keesha Dyal, Brenda Chamala, Srikar Yao, Yingwei Fillingim, Roger Wang, Zajie Molokie, Robert Wilkie, Diana Innov Aging Abstracts Purpose: Emotional stress is a known pain trigger in patients with sickle cell disease (SCD). The Arginine vasopressin receptor 1A gene (AVPR1A), SNP rs10877969, is associated with acute pain and stress-related pain. Our study investigated the association between AVPR1A genotype with stress and age in adults with SCD pain. Methods: 169 participants with SCD and chronic pain (100% African descent; mean age 36.4 ± 11.6 years [range =18-74 years]) completed the Perceived Stress Questionnaire. The SNP was evaluated as the imputed score was R2>0.8. ANOVA compared stress by genotype and age. Findings: Mean stress scores were significantly lower (p<0.05) for the older adults (0.35 ± 0.18) than the younger adults (0.41 ± 0.17). Mean stress scores were not significantly different by genotype for younger or older adults. Discussion: The rs10877969 genotype frequency was not different by age. In contrast to prior research, there was no association between genotype and stress. Oxford University Press 2020-12-16 /pmc/articles/PMC7742995/ http://dx.doi.org/10.1093/geroni/igaa057.2843 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of The Gerontological Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Abstracts Roach, Keesha Dyal, Brenda Chamala, Srikar Yao, Yingwei Fillingim, Roger Wang, Zajie Molokie, Robert Wilkie, Diana AVPR1A and Stress in Adults With Sickle Cell Disease–Related Chronic Pain |
title | AVPR1A and Stress in Adults With Sickle Cell Disease–Related Chronic Pain |
title_full | AVPR1A and Stress in Adults With Sickle Cell Disease–Related Chronic Pain |
title_fullStr | AVPR1A and Stress in Adults With Sickle Cell Disease–Related Chronic Pain |
title_full_unstemmed | AVPR1A and Stress in Adults With Sickle Cell Disease–Related Chronic Pain |
title_short | AVPR1A and Stress in Adults With Sickle Cell Disease–Related Chronic Pain |
title_sort | avpr1a and stress in adults with sickle cell disease–related chronic pain |
topic | Abstracts |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7742995/ http://dx.doi.org/10.1093/geroni/igaa057.2843 |
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