The D614G Mutation Enhances the Lysosomal Trafficking of SARS-CoV-2 Spike

The spike D614G mutation increases SARS-CoV-2 infectivity, viral load, and transmission but the molecular mechanism underlying these effects remains unclear. We report here that spike is trafficked to lysosomes and that the D614G mutation enhances the lysosomal sorting of spike and the lysosomal acc...

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Detalles Bibliográficos
Autores principales: Guo, Chenxu, Tsai, Shang-Jui, Ai, Yiwei, Li, Maggie, Pekosz, Andrew, Cox, Andrea, Atai, Nadia, Gould, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7743070/
https://www.ncbi.nlm.nih.gov/pubmed/33330866
http://dx.doi.org/10.1101/2020.12.08.417022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7743070/
https://www.ncbi.nlm.nih.gov/pubmed/33330866
http://dx.doi.org/10.1101/2020.12.08.417022

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