Persistent Cellular Immunity to SARS-CoV-2 Infection

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SARS-CoV-2 is responsible for an ongoing pandemic that affected millions of individuals around the globe. To gain further understanding of the immune response in recovered individuals we measured T cell responses in paired samples obtained an average of 1.3 and 6.1 months after infection from 41 ind...

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Detalles Bibliográficos
Autores principales: Breton, Gaëlle, Mendoza, Pilar, Hagglof, Thomas, Oliveira, Thiago Y., Schaefer-Babajew, Dennis, Gaebler, Christian, Turroja, Martina, Hurley, Arlene, Caskey, Marina, Nussenzweig, Michel C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7743071/
https://www.ncbi.nlm.nih.gov/pubmed/33330867
http://dx.doi.org/10.1101/2020.12.08.416636
Descripción
Sumario:SARS-CoV-2 is responsible for an ongoing pandemic that affected millions of individuals around the globe. To gain further understanding of the immune response in recovered individuals we measured T cell responses in paired samples obtained an average of 1.3 and 6.1 months after infection from 41 individuals. The data indicate that recovered individuals show persistent polyfunctional SARS-CoV-2 antigen specific memory that could contribute to rapid recall responses. In addition, recovered individuals show enduring immune alterations in relative numbers of CD4(+) and CD8(+) T cells, expression of activation/exhaustion markers, and cell division.

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