Persistent Cellular Immunity to SARS-CoV-2 Infection

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SARS-CoV-2 is responsible for an ongoing pandemic that affected millions of individuals around the globe. To gain further understanding of the immune response in recovered individuals we measured T cell responses in paired samples obtained an average of 1.3 and 6.1 months after infection from 41 ind...

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Autores principales: Breton, Gaëlle, Mendoza, Pilar, Hagglof, Thomas, Oliveira, Thiago Y., Schaefer-Babajew, Dennis, Gaebler, Christian, Turroja, Martina, Hurley, Arlene, Caskey, Marina, Nussenzweig, Michel C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7743071/
https://www.ncbi.nlm.nih.gov/pubmed/33330867
http://dx.doi.org/10.1101/2020.12.08.416636
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author Breton, Gaëlle
Mendoza, Pilar
Hagglof, Thomas
Oliveira, Thiago Y.
Schaefer-Babajew, Dennis
Gaebler, Christian
Turroja, Martina
Hurley, Arlene
Caskey, Marina
Nussenzweig, Michel C.
author_facet Breton, Gaëlle
Mendoza, Pilar
Hagglof, Thomas
Oliveira, Thiago Y.
Schaefer-Babajew, Dennis
Gaebler, Christian
Turroja, Martina
Hurley, Arlene
Caskey, Marina
Nussenzweig, Michel C.
author_sort Breton, Gaëlle
collection PubMed
description SARS-CoV-2 is responsible for an ongoing pandemic that affected millions of individuals around the globe. To gain further understanding of the immune response in recovered individuals we measured T cell responses in paired samples obtained an average of 1.3 and 6.1 months after infection from 41 individuals. The data indicate that recovered individuals show persistent polyfunctional SARS-CoV-2 antigen specific memory that could contribute to rapid recall responses. In addition, recovered individuals show enduring immune alterations in relative numbers of CD4(+) and CD8(+) T cells, expression of activation/exhaustion markers, and cell division.
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spelling pubmed-77430712020-12-17 Persistent Cellular Immunity to SARS-CoV-2 Infection Breton, Gaëlle Mendoza, Pilar Hagglof, Thomas Oliveira, Thiago Y. Schaefer-Babajew, Dennis Gaebler, Christian Turroja, Martina Hurley, Arlene Caskey, Marina Nussenzweig, Michel C. bioRxiv Article SARS-CoV-2 is responsible for an ongoing pandemic that affected millions of individuals around the globe. To gain further understanding of the immune response in recovered individuals we measured T cell responses in paired samples obtained an average of 1.3 and 6.1 months after infection from 41 individuals. The data indicate that recovered individuals show persistent polyfunctional SARS-CoV-2 antigen specific memory that could contribute to rapid recall responses. In addition, recovered individuals show enduring immune alterations in relative numbers of CD4(+) and CD8(+) T cells, expression of activation/exhaustion markers, and cell division. Cold Spring Harbor Laboratory 2020-12-09 /pmc/articles/PMC7743071/ /pubmed/33330867 http://dx.doi.org/10.1101/2020.12.08.416636 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator.
spellingShingle Article
Breton, Gaëlle
Mendoza, Pilar
Hagglof, Thomas
Oliveira, Thiago Y.
Schaefer-Babajew, Dennis
Gaebler, Christian
Turroja, Martina
Hurley, Arlene
Caskey, Marina
Nussenzweig, Michel C.
Persistent Cellular Immunity to SARS-CoV-2 Infection
title Persistent Cellular Immunity to SARS-CoV-2 Infection
title_full Persistent Cellular Immunity to SARS-CoV-2 Infection
title_fullStr Persistent Cellular Immunity to SARS-CoV-2 Infection
title_full_unstemmed Persistent Cellular Immunity to SARS-CoV-2 Infection
title_short Persistent Cellular Immunity to SARS-CoV-2 Infection
title_sort persistent cellular immunity to sars-cov-2 infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7743071/
https://www.ncbi.nlm.nih.gov/pubmed/33330867
http://dx.doi.org/10.1101/2020.12.08.416636
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