Thiol drugs decrease SARS-CoV-2 lung injury in vivo and disrupt SARS-CoV-2 spike complex binding to ACE2 in vitro

Neutrophil-induced oxidative stress is a mechanism of lung injury in COVID-19, and drugs with a functional thiol group (“thiol drugs”), especially cysteamine, have anti-oxidant and anti-inflammatory properties that could limit this injury. Thiol drugs may also alter the redox status of the cysteine-...

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Detalles Bibliográficos
Autores principales: Khanna, Kritika, Raymond, Wilfred, Jin, Jing, Charbit, Annabelle R., Gitlin, Irina, Tang, Monica, Werts, Adam D., Barrett, Edward G., Cox, Jason M., Birch, Sharla M., Martinelli, Rachel, Sperber, Hannah S., Franz, Sergej, Pillai, Satish, Healy, Anne Marie, Duff, Thomas, Oscarson, Stefan, Hoffmann, Markus, Pöhlmann, Stefan, Simmons, Graham, Fahy, John V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7743076/
https://www.ncbi.nlm.nih.gov/pubmed/33330868
http://dx.doi.org/10.1101/2020.12.08.415505

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