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Activation of Interferon-Stimulated Transcriptomes and ACE2 Isoforms in Human Airway Epithelium Is Curbed by Janus Kinase Inhibitors

SARS-CoV-2 infection of human airway epithelium activates genetic programs that lead to progressive hyperinflammation in COVID-19 patients. Here we report on genetic programs activated by interferons and the suppression by Janus kinase (JAK) inhibitors. The angiotensin-converting enzyme 2 (ACE2) is...

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Detalles Bibliográficos
Autores principales:	Lee, Hye Kyung, Jung, Olive, Hennighausen, Lothar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Journal Experts 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7743079/ https://www.ncbi.nlm.nih.gov/pubmed/33330857 http://dx.doi.org/10.21203/rs.3.rs-119695/v1

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