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Race and Regional Differences in Risk Factors for Cognitive Impairment From a Combined Cohort Analysis
Few studies examined race-regional influences on mild cognitive impairment (MCI) and dementia risk factors. We examined 14 risk factors in 5 race-regions, e.g. cross-sectional age- and sex-adjusted relative prevalence ratios (RPR) from multinomial regression comparing associations of low education (...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7743294/ http://dx.doi.org/10.1093/geroni/igaa057.2828 |
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author | Windham, B Gwen Griswold, Michael Henegan, James Knopman, David Lirette, Seth Mielke, Michelle Petersen, Ron Mosley, Thomas |
author_facet | Windham, B Gwen Griswold, Michael Henegan, James Knopman, David Lirette, Seth Mielke, Michelle Petersen, Ron Mosley, Thomas |
author_sort | Windham, B Gwen |
collection | PubMed |
description | Few studies examined race-regional influences on mild cognitive impairment (MCI) and dementia risk factors. We examined 14 risk factors in 5 race-regions, e.g. cross-sectional age- and sex-adjusted relative prevalence ratios (RPR) from multinomial regression comparing associations of low education (<12yrs) with MCI and dementia (versus normal cognition) across 3 race-region groups, average age 76yrs: whites in the Mayo Clinic Study of Aging[MCSA, Olmsted County, MN—MCSA-MN-Whites); Atherosclerosis Risk in Communities(ARIC) whites in suburban Minneapolis, MN—ARIC-MN-Whites); ARIC-African Americans in Jackson, MS—ARIC-MS-AA. Among 3,787 MCSA-Whites, low education exerted a 2-fold risk for MCI, RPR=2.09(95%CI: 1.57,2.78). Conversely, low education was not a supported MCI risk factor for ARIC-MN-Whites (n=1,901—RPR=0.63(0.31,1.28) or ARIC-MS-AA, (n=1,416—RPR=.0.81 (0.60,1.10)), with substantially differential race-region effects. Low education RPRs for dementia also differed by race-region: RPR=4.43(2.68,7.31-MCSA-MN-W), RPR=0.70 (0.16,2.99-ARIC-MN-Whites), and RPR=2.54 (1.74,3.72-ARIC-MS-AA). Understanding why risk factors differ by race and region likely requires diverse samples and harmonized methods using culturally-appropriate assessments. |
format | Online Article Text |
id | pubmed-7743294 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-77432942020-12-21 Race and Regional Differences in Risk Factors for Cognitive Impairment From a Combined Cohort Analysis Windham, B Gwen Griswold, Michael Henegan, James Knopman, David Lirette, Seth Mielke, Michelle Petersen, Ron Mosley, Thomas Innov Aging Abstracts Few studies examined race-regional influences on mild cognitive impairment (MCI) and dementia risk factors. We examined 14 risk factors in 5 race-regions, e.g. cross-sectional age- and sex-adjusted relative prevalence ratios (RPR) from multinomial regression comparing associations of low education (<12yrs) with MCI and dementia (versus normal cognition) across 3 race-region groups, average age 76yrs: whites in the Mayo Clinic Study of Aging[MCSA, Olmsted County, MN—MCSA-MN-Whites); Atherosclerosis Risk in Communities(ARIC) whites in suburban Minneapolis, MN—ARIC-MN-Whites); ARIC-African Americans in Jackson, MS—ARIC-MS-AA. Among 3,787 MCSA-Whites, low education exerted a 2-fold risk for MCI, RPR=2.09(95%CI: 1.57,2.78). Conversely, low education was not a supported MCI risk factor for ARIC-MN-Whites (n=1,901—RPR=0.63(0.31,1.28) or ARIC-MS-AA, (n=1,416—RPR=.0.81 (0.60,1.10)), with substantially differential race-region effects. Low education RPRs for dementia also differed by race-region: RPR=4.43(2.68,7.31-MCSA-MN-W), RPR=0.70 (0.16,2.99-ARIC-MN-Whites), and RPR=2.54 (1.74,3.72-ARIC-MS-AA). Understanding why risk factors differ by race and region likely requires diverse samples and harmonized methods using culturally-appropriate assessments. Oxford University Press 2020-12-16 /pmc/articles/PMC7743294/ http://dx.doi.org/10.1093/geroni/igaa057.2828 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of The Gerontological Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Abstracts Windham, B Gwen Griswold, Michael Henegan, James Knopman, David Lirette, Seth Mielke, Michelle Petersen, Ron Mosley, Thomas Race and Regional Differences in Risk Factors for Cognitive Impairment From a Combined Cohort Analysis |
title | Race and Regional Differences in Risk Factors for Cognitive Impairment From a Combined Cohort Analysis |
title_full | Race and Regional Differences in Risk Factors for Cognitive Impairment From a Combined Cohort Analysis |
title_fullStr | Race and Regional Differences in Risk Factors for Cognitive Impairment From a Combined Cohort Analysis |
title_full_unstemmed | Race and Regional Differences in Risk Factors for Cognitive Impairment From a Combined Cohort Analysis |
title_short | Race and Regional Differences in Risk Factors for Cognitive Impairment From a Combined Cohort Analysis |
title_sort | race and regional differences in risk factors for cognitive impairment from a combined cohort analysis |
topic | Abstracts |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7743294/ http://dx.doi.org/10.1093/geroni/igaa057.2828 |
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