Cargando…
Differences in Longitudinal Fasting Blood Glucose and Mortality Risk Across the Lifespan Between Mice and Humans
Aging profoundly affects metabolism where trajectories of metabolic indices serve as strong predictors of health, disease and mortality. Mice and non-human primates are widely used to model all aspects of human biology, including metabolism. However, there is limited knowledge on how different speci...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7743601/ http://dx.doi.org/10.1093/geroni/igaa057.1672 |
_version_ | 1783624256228163584 |
---|---|
author | Palliyaguru, Dushani Shiroma, Eric Nam, John Ferrucci, Luigi de Cabo, Rafael |
author_facet | Palliyaguru, Dushani Shiroma, Eric Nam, John Ferrucci, Luigi de Cabo, Rafael |
author_sort | Palliyaguru, Dushani |
collection | PubMed |
description | Aging profoundly affects metabolism where trajectories of metabolic indices serve as strong predictors of health, disease and mortality. Mice and non-human primates are widely used to model all aspects of human biology, including metabolism. However, there is limited knowledge on how different species metabolically age during their life course. Here, we compare longitudinal predictors of health and mortality of three major metabolic indices among mice, non-human primates and humans. Longitudinal fasting blood glucose, body weight and body composition over the lifespan were compared across species in mice (Study of Longitudinal Aging in Mice), Rhesus monkeys (NIA and Wisconsin colonies) and humans (Baltimore Longitudinal Study on Aging). Survival analysis was conducted to calculate the risk of death for subjects with highest and lowest quartiles of fasting blood glucose. We will present data highlighting species-specific mechanisms of glucose homeostasis over the lifespan and its association with mortality. |
format | Online Article Text |
id | pubmed-7743601 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-77436012020-12-21 Differences in Longitudinal Fasting Blood Glucose and Mortality Risk Across the Lifespan Between Mice and Humans Palliyaguru, Dushani Shiroma, Eric Nam, John Ferrucci, Luigi de Cabo, Rafael Innov Aging Abstracts Aging profoundly affects metabolism where trajectories of metabolic indices serve as strong predictors of health, disease and mortality. Mice and non-human primates are widely used to model all aspects of human biology, including metabolism. However, there is limited knowledge on how different species metabolically age during their life course. Here, we compare longitudinal predictors of health and mortality of three major metabolic indices among mice, non-human primates and humans. Longitudinal fasting blood glucose, body weight and body composition over the lifespan were compared across species in mice (Study of Longitudinal Aging in Mice), Rhesus monkeys (NIA and Wisconsin colonies) and humans (Baltimore Longitudinal Study on Aging). Survival analysis was conducted to calculate the risk of death for subjects with highest and lowest quartiles of fasting blood glucose. We will present data highlighting species-specific mechanisms of glucose homeostasis over the lifespan and its association with mortality. Oxford University Press 2020-12-16 /pmc/articles/PMC7743601/ http://dx.doi.org/10.1093/geroni/igaa057.1672 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of The Gerontological Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Abstracts Palliyaguru, Dushani Shiroma, Eric Nam, John Ferrucci, Luigi de Cabo, Rafael Differences in Longitudinal Fasting Blood Glucose and Mortality Risk Across the Lifespan Between Mice and Humans |
title | Differences in Longitudinal Fasting Blood Glucose and Mortality Risk Across the Lifespan Between Mice and Humans |
title_full | Differences in Longitudinal Fasting Blood Glucose and Mortality Risk Across the Lifespan Between Mice and Humans |
title_fullStr | Differences in Longitudinal Fasting Blood Glucose and Mortality Risk Across the Lifespan Between Mice and Humans |
title_full_unstemmed | Differences in Longitudinal Fasting Blood Glucose and Mortality Risk Across the Lifespan Between Mice and Humans |
title_short | Differences in Longitudinal Fasting Blood Glucose and Mortality Risk Across the Lifespan Between Mice and Humans |
title_sort | differences in longitudinal fasting blood glucose and mortality risk across the lifespan between mice and humans |
topic | Abstracts |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7743601/ http://dx.doi.org/10.1093/geroni/igaa057.1672 |
work_keys_str_mv | AT palliyagurudushani differencesinlongitudinalfastingbloodglucoseandmortalityriskacrossthelifespanbetweenmiceandhumans AT shiromaeric differencesinlongitudinalfastingbloodglucoseandmortalityriskacrossthelifespanbetweenmiceandhumans AT namjohn differencesinlongitudinalfastingbloodglucoseandmortalityriskacrossthelifespanbetweenmiceandhumans AT ferrucciluigi differencesinlongitudinalfastingbloodglucoseandmortalityriskacrossthelifespanbetweenmiceandhumans AT decaborafael differencesinlongitudinalfastingbloodglucoseandmortalityriskacrossthelifespanbetweenmiceandhumans AT differencesinlongitudinalfastingbloodglucoseandmortalityriskacrossthelifespanbetweenmiceandhumans |