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Differences in Longitudinal Fasting Blood Glucose and Mortality Risk Across the Lifespan Between Mice and Humans

Aging profoundly affects metabolism where trajectories of metabolic indices serve as strong predictors of health, disease and mortality. Mice and non-human primates are widely used to model all aspects of human biology, including metabolism. However, there is limited knowledge on how different speci...

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Autores principales: Palliyaguru, Dushani, Shiroma, Eric, Nam, John, Ferrucci, Luigi, de Cabo, Rafael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7743601/
http://dx.doi.org/10.1093/geroni/igaa057.1672
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author Palliyaguru, Dushani
Shiroma, Eric
Nam, John
Ferrucci, Luigi
de Cabo, Rafael
author_facet Palliyaguru, Dushani
Shiroma, Eric
Nam, John
Ferrucci, Luigi
de Cabo, Rafael
author_sort Palliyaguru, Dushani
collection PubMed
description Aging profoundly affects metabolism where trajectories of metabolic indices serve as strong predictors of health, disease and mortality. Mice and non-human primates are widely used to model all aspects of human biology, including metabolism. However, there is limited knowledge on how different species metabolically age during their life course. Here, we compare longitudinal predictors of health and mortality of three major metabolic indices among mice, non-human primates and humans. Longitudinal fasting blood glucose, body weight and body composition over the lifespan were compared across species in mice (Study of Longitudinal Aging in Mice), Rhesus monkeys (NIA and Wisconsin colonies) and humans (Baltimore Longitudinal Study on Aging). Survival analysis was conducted to calculate the risk of death for subjects with highest and lowest quartiles of fasting blood glucose. We will present data highlighting species-specific mechanisms of glucose homeostasis over the lifespan and its association with mortality.
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spelling pubmed-77436012020-12-21 Differences in Longitudinal Fasting Blood Glucose and Mortality Risk Across the Lifespan Between Mice and Humans Palliyaguru, Dushani Shiroma, Eric Nam, John Ferrucci, Luigi de Cabo, Rafael Innov Aging Abstracts Aging profoundly affects metabolism where trajectories of metabolic indices serve as strong predictors of health, disease and mortality. Mice and non-human primates are widely used to model all aspects of human biology, including metabolism. However, there is limited knowledge on how different species metabolically age during their life course. Here, we compare longitudinal predictors of health and mortality of three major metabolic indices among mice, non-human primates and humans. Longitudinal fasting blood glucose, body weight and body composition over the lifespan were compared across species in mice (Study of Longitudinal Aging in Mice), Rhesus monkeys (NIA and Wisconsin colonies) and humans (Baltimore Longitudinal Study on Aging). Survival analysis was conducted to calculate the risk of death for subjects with highest and lowest quartiles of fasting blood glucose. We will present data highlighting species-specific mechanisms of glucose homeostasis over the lifespan and its association with mortality. Oxford University Press 2020-12-16 /pmc/articles/PMC7743601/ http://dx.doi.org/10.1093/geroni/igaa057.1672 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of The Gerontological Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstracts
Palliyaguru, Dushani
Shiroma, Eric
Nam, John
Ferrucci, Luigi
de Cabo, Rafael
Differences in Longitudinal Fasting Blood Glucose and Mortality Risk Across the Lifespan Between Mice and Humans
title Differences in Longitudinal Fasting Blood Glucose and Mortality Risk Across the Lifespan Between Mice and Humans
title_full Differences in Longitudinal Fasting Blood Glucose and Mortality Risk Across the Lifespan Between Mice and Humans
title_fullStr Differences in Longitudinal Fasting Blood Glucose and Mortality Risk Across the Lifespan Between Mice and Humans
title_full_unstemmed Differences in Longitudinal Fasting Blood Glucose and Mortality Risk Across the Lifespan Between Mice and Humans
title_short Differences in Longitudinal Fasting Blood Glucose and Mortality Risk Across the Lifespan Between Mice and Humans
title_sort differences in longitudinal fasting blood glucose and mortality risk across the lifespan between mice and humans
topic Abstracts
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7743601/
http://dx.doi.org/10.1093/geroni/igaa057.1672
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