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Multimodal Neuroimaging Predictors of Gait Decline
Prior studies suggesting associations between cortical brain areas and gait speed has been largely cross-sectional and limited to one modality neuroimaging. Using machine learning from 506 cognitively normal BLSA participants aged 55+ who had repeated measures of brain volumes, diffusion tensor imag...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7743666/ http://dx.doi.org/10.1093/geroni/igaa057.2769 |
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author | Sargent, Lana Tian, Qu Nalls, Mike Singleton, Andrew Studenski, Stephanie Resnick, Susan Ferrucci, Luigi |
author_facet | Sargent, Lana Tian, Qu Nalls, Mike Singleton, Andrew Studenski, Stephanie Resnick, Susan Ferrucci, Luigi |
author_sort | Sargent, Lana |
collection | PubMed |
description | Prior studies suggesting associations between cortical brain areas and gait speed has been largely cross-sectional and limited to one modality neuroimaging. Using machine learning from 506 cognitively normal BLSA participants aged 55+ who had repeated measures of brain volumes, diffusion tensor imaging (DTI), and gait speed, we examined multimodal neuroimaging predictors of gait decline, accounting for demographics, body composition, and grip strength. Significant predictors of gait decline included changes in volumes and DTI measures of gray matter in selected frontal, parietal, temporal, and subcortical areas, as well as white matter changes in both fractional anisotropy and diffusivity of tracts connecting frontal areas to subcortical motor areas. This predictive model highlights the importance of atrophy and microstructural deterioration in selected frontal and subcortical motor areas in predicting gait speed decline. |
format | Online Article Text |
id | pubmed-7743666 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-77436662020-12-21 Multimodal Neuroimaging Predictors of Gait Decline Sargent, Lana Tian, Qu Nalls, Mike Singleton, Andrew Studenski, Stephanie Resnick, Susan Ferrucci, Luigi Innov Aging Abstracts Prior studies suggesting associations between cortical brain areas and gait speed has been largely cross-sectional and limited to one modality neuroimaging. Using machine learning from 506 cognitively normal BLSA participants aged 55+ who had repeated measures of brain volumes, diffusion tensor imaging (DTI), and gait speed, we examined multimodal neuroimaging predictors of gait decline, accounting for demographics, body composition, and grip strength. Significant predictors of gait decline included changes in volumes and DTI measures of gray matter in selected frontal, parietal, temporal, and subcortical areas, as well as white matter changes in both fractional anisotropy and diffusivity of tracts connecting frontal areas to subcortical motor areas. This predictive model highlights the importance of atrophy and microstructural deterioration in selected frontal and subcortical motor areas in predicting gait speed decline. Oxford University Press 2020-12-16 /pmc/articles/PMC7743666/ http://dx.doi.org/10.1093/geroni/igaa057.2769 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of The Gerontological Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Abstracts Sargent, Lana Tian, Qu Nalls, Mike Singleton, Andrew Studenski, Stephanie Resnick, Susan Ferrucci, Luigi Multimodal Neuroimaging Predictors of Gait Decline |
title | Multimodal Neuroimaging Predictors of Gait Decline |
title_full | Multimodal Neuroimaging Predictors of Gait Decline |
title_fullStr | Multimodal Neuroimaging Predictors of Gait Decline |
title_full_unstemmed | Multimodal Neuroimaging Predictors of Gait Decline |
title_short | Multimodal Neuroimaging Predictors of Gait Decline |
title_sort | multimodal neuroimaging predictors of gait decline |
topic | Abstracts |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7743666/ http://dx.doi.org/10.1093/geroni/igaa057.2769 |
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