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The Effects of INDY on Fly Metabolism
The Indy (I’m not dead yet) gene encodes a plasma membrane citrate transporter in Drosophila. INDY reduction affects metabolism and extends longevity of flies and worms. In flies, INDY is predominantly expressed in the midgut, fat body and oenocytes, tissues with a key role in metabolism. We hypothe...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7743797/ http://dx.doi.org/10.1093/geroni/igaa057.2622 |
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author | Rogina, Blanka Kannan, Kavitha Mishra, Dushyant Macro, Jacob Lesperance, Danielle Broderick, Nichole Padhi, Shivani Rosenbloom-Snow, Aaron |
author_facet | Rogina, Blanka Kannan, Kavitha Mishra, Dushyant Macro, Jacob Lesperance, Danielle Broderick, Nichole Padhi, Shivani Rosenbloom-Snow, Aaron |
author_sort | Rogina, Blanka |
collection | PubMed |
description | The Indy (I’m not dead yet) gene encodes a plasma membrane citrate transporter in Drosophila. INDY reduction affects metabolism and extends longevity of flies and worms. In flies, INDY is predominantly expressed in the midgut, fat body and oenocytes, tissues with a key role in metabolism. We hypothesize that INDY reduction in the midgut regulates citrate levels leading to metabolic changes that preserve intestinal stem cell (ISC) homeostasis and slows aging by modifying Insulin/Insulin-like signaling (IIS), which is a key nutrient sensing pathway. Our second goal was to examine the role of JAK/STAT signaling pathway, which activates epithelial renewal in the gut, in response to aging-related stressors. We hypothesize that Indy reduction has effects on the microbiome, preventing bacterial overgrowth and altering community diversity, leading to extended longevity in a JAK/STAT-mediated fashion. Our data suggest that effects of Indy reduction is mediated by reduced IIS and JAK/STAT pathways |
format | Online Article Text |
id | pubmed-7743797 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-77437972020-12-21 The Effects of INDY on Fly Metabolism Rogina, Blanka Kannan, Kavitha Mishra, Dushyant Macro, Jacob Lesperance, Danielle Broderick, Nichole Padhi, Shivani Rosenbloom-Snow, Aaron Innov Aging Abstracts The Indy (I’m not dead yet) gene encodes a plasma membrane citrate transporter in Drosophila. INDY reduction affects metabolism and extends longevity of flies and worms. In flies, INDY is predominantly expressed in the midgut, fat body and oenocytes, tissues with a key role in metabolism. We hypothesize that INDY reduction in the midgut regulates citrate levels leading to metabolic changes that preserve intestinal stem cell (ISC) homeostasis and slows aging by modifying Insulin/Insulin-like signaling (IIS), which is a key nutrient sensing pathway. Our second goal was to examine the role of JAK/STAT signaling pathway, which activates epithelial renewal in the gut, in response to aging-related stressors. We hypothesize that Indy reduction has effects on the microbiome, preventing bacterial overgrowth and altering community diversity, leading to extended longevity in a JAK/STAT-mediated fashion. Our data suggest that effects of Indy reduction is mediated by reduced IIS and JAK/STAT pathways Oxford University Press 2020-12-16 /pmc/articles/PMC7743797/ http://dx.doi.org/10.1093/geroni/igaa057.2622 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of The Gerontological Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Abstracts Rogina, Blanka Kannan, Kavitha Mishra, Dushyant Macro, Jacob Lesperance, Danielle Broderick, Nichole Padhi, Shivani Rosenbloom-Snow, Aaron The Effects of INDY on Fly Metabolism |
title | The Effects of INDY on Fly Metabolism |
title_full | The Effects of INDY on Fly Metabolism |
title_fullStr | The Effects of INDY on Fly Metabolism |
title_full_unstemmed | The Effects of INDY on Fly Metabolism |
title_short | The Effects of INDY on Fly Metabolism |
title_sort | effects of indy on fly metabolism |
topic | Abstracts |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7743797/ http://dx.doi.org/10.1093/geroni/igaa057.2622 |
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