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Retinal Microvascular Health: Can the Eye Tell Us About the Brain?

Cognitive impairment caused by Alzheimer’s and other dementias is linked to vascular damage in the brain. Early microvascular changes in the brain are difficult to detect but in the retina, they can potentially be seen using optical coherence tomographic angiography. In cross-sectional analysis, ass...

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Autores principales: Abraham, Alison, Guo, Xinxing, Kong, Xiangrong, Sharrett, A Richey, Lujan, Brandon, Huang, David, Ramulu, Pradeep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7743854/
http://dx.doi.org/10.1093/geroni/igaa057.2923
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author Abraham, Alison
Guo, Xinxing
Kong, Xiangrong
Sharrett, A Richey
Lujan, Brandon
Huang, David
Ramulu, Pradeep
author_facet Abraham, Alison
Guo, Xinxing
Kong, Xiangrong
Sharrett, A Richey
Lujan, Brandon
Huang, David
Ramulu, Pradeep
author_sort Abraham, Alison
collection PubMed
description Cognitive impairment caused by Alzheimer’s and other dementias is linked to vascular damage in the brain. Early microvascular changes in the brain are difficult to detect but in the retina, they can potentially be seen using optical coherence tomographic angiography. In cross-sectional analysis, associations between retinal vessel density (VD) and cognitive performance were assessed by regression analysis of cognitive function z-scores (for global function as well as language, memory and executive function domains) on VD, controlling for age, race and education. Among 177 participants without dementia (50% black; 67% female; mean age 78 years [range: 71-93 years]), the mean (SD) superficial vascular complex VD was 48.0% (7.2). Among the 191 eyes without eye disease, there were no significant associations of VD with global or domain specific cognitive function. Early changes in the eye related to systemic disease processes may not currently be detectable in healthy older adults with imaging data.
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spelling pubmed-77438542020-12-21 Retinal Microvascular Health: Can the Eye Tell Us About the Brain? Abraham, Alison Guo, Xinxing Kong, Xiangrong Sharrett, A Richey Lujan, Brandon Huang, David Ramulu, Pradeep Innov Aging Abstracts Cognitive impairment caused by Alzheimer’s and other dementias is linked to vascular damage in the brain. Early microvascular changes in the brain are difficult to detect but in the retina, they can potentially be seen using optical coherence tomographic angiography. In cross-sectional analysis, associations between retinal vessel density (VD) and cognitive performance were assessed by regression analysis of cognitive function z-scores (for global function as well as language, memory and executive function domains) on VD, controlling for age, race and education. Among 177 participants without dementia (50% black; 67% female; mean age 78 years [range: 71-93 years]), the mean (SD) superficial vascular complex VD was 48.0% (7.2). Among the 191 eyes without eye disease, there were no significant associations of VD with global or domain specific cognitive function. Early changes in the eye related to systemic disease processes may not currently be detectable in healthy older adults with imaging data. Oxford University Press 2020-12-16 /pmc/articles/PMC7743854/ http://dx.doi.org/10.1093/geroni/igaa057.2923 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of The Gerontological Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstracts
Abraham, Alison
Guo, Xinxing
Kong, Xiangrong
Sharrett, A Richey
Lujan, Brandon
Huang, David
Ramulu, Pradeep
Retinal Microvascular Health: Can the Eye Tell Us About the Brain?
title Retinal Microvascular Health: Can the Eye Tell Us About the Brain?
title_full Retinal Microvascular Health: Can the Eye Tell Us About the Brain?
title_fullStr Retinal Microvascular Health: Can the Eye Tell Us About the Brain?
title_full_unstemmed Retinal Microvascular Health: Can the Eye Tell Us About the Brain?
title_short Retinal Microvascular Health: Can the Eye Tell Us About the Brain?
title_sort retinal microvascular health: can the eye tell us about the brain?
topic Abstracts
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7743854/
http://dx.doi.org/10.1093/geroni/igaa057.2923
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