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Medial Temporal Tau Pathology Is Associated With Verbal Memory

Medial temporal tau pathology is frequently observed in individuals over 70 regardless of cognitive status. To understand the link between tau and cognitive performance, we evaluated tau pathology using 18F-flortaucipir positron emission tomography among 95 cognitively normal participants from the B...

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Autores principales: Bilgel, Murat, Ziontz, Jacob, Shafer, Andrea, Ferrucci, Luigi, Wong, Dean, Resnick, Susan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7743860/
http://dx.doi.org/10.1093/geroni/igaa057.2770
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author Bilgel, Murat
Ziontz, Jacob
Shafer, Andrea
Ferrucci, Luigi
Wong, Dean
Resnick, Susan
author_facet Bilgel, Murat
Ziontz, Jacob
Shafer, Andrea
Ferrucci, Luigi
Wong, Dean
Resnick, Susan
author_sort Bilgel, Murat
collection PubMed
description Medial temporal tau pathology is frequently observed in individuals over 70 regardless of cognitive status. To understand the link between tau and cognitive performance, we evaluated tau pathology using 18F-flortaucipir positron emission tomography among 95 cognitively normal participants from the Baltimore Longitudinal Study of Aging. We examined tau levels in early Braak regions (entorhinal cortex and hippocampus) in relation to verbal episodic memory performance concurrent with and prior to the tau scan using linear mixed effects models adjusted for age, sex, amyloid status, and time from PET scan. Higher hippocampal tau burden had a trend-level association with lower concurrent memory performance (p=0.05). Greater tau pathology in the hippocampus and entorhinal cortex was associated with steeper decline in memory performance prior to tau scan (p=0.013 and 0.026, respectively). These findings suggest that therapeutic interventions targeting tau pathology may need to be administered early among cognitively normal individuals to prevent memory decline.
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spelling pubmed-77438602020-12-22 Medial Temporal Tau Pathology Is Associated With Verbal Memory Bilgel, Murat Ziontz, Jacob Shafer, Andrea Ferrucci, Luigi Wong, Dean Resnick, Susan Innov Aging Abstracts Medial temporal tau pathology is frequently observed in individuals over 70 regardless of cognitive status. To understand the link between tau and cognitive performance, we evaluated tau pathology using 18F-flortaucipir positron emission tomography among 95 cognitively normal participants from the Baltimore Longitudinal Study of Aging. We examined tau levels in early Braak regions (entorhinal cortex and hippocampus) in relation to verbal episodic memory performance concurrent with and prior to the tau scan using linear mixed effects models adjusted for age, sex, amyloid status, and time from PET scan. Higher hippocampal tau burden had a trend-level association with lower concurrent memory performance (p=0.05). Greater tau pathology in the hippocampus and entorhinal cortex was associated with steeper decline in memory performance prior to tau scan (p=0.013 and 0.026, respectively). These findings suggest that therapeutic interventions targeting tau pathology may need to be administered early among cognitively normal individuals to prevent memory decline. Oxford University Press 2020-12-16 /pmc/articles/PMC7743860/ http://dx.doi.org/10.1093/geroni/igaa057.2770 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of The Gerontological Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstracts
Bilgel, Murat
Ziontz, Jacob
Shafer, Andrea
Ferrucci, Luigi
Wong, Dean
Resnick, Susan
Medial Temporal Tau Pathology Is Associated With Verbal Memory
title Medial Temporal Tau Pathology Is Associated With Verbal Memory
title_full Medial Temporal Tau Pathology Is Associated With Verbal Memory
title_fullStr Medial Temporal Tau Pathology Is Associated With Verbal Memory
title_full_unstemmed Medial Temporal Tau Pathology Is Associated With Verbal Memory
title_short Medial Temporal Tau Pathology Is Associated With Verbal Memory
title_sort medial temporal tau pathology is associated with verbal memory
topic Abstracts
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7743860/
http://dx.doi.org/10.1093/geroni/igaa057.2770
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