Sirtuins: New Roles for Sirtuins in Aging and Disease

Sirtuins are NAD+-dependent enzymes related to yeast silent information regulator-2, a histone deacetylase that prevents premature aging through chromatin silencing. Mammalian sirtuins, SIRT1-SIRT7, have key functions that protect against diverse aging-related pathologic states, from cancer to metab...

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Detalles Bibliográficos
Autor principal: Chua, Katrin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7743872/
http://dx.doi.org/10.1093/geroni/igaa057.2650
Descripción
Sumario:Sirtuins are NAD+-dependent enzymes related to yeast silent information regulator-2, a histone deacetylase that prevents premature aging through chromatin silencing. Mammalian sirtuins, SIRT1-SIRT7, have key functions that protect against diverse aging-related pathologic states, from cancer to metabolic and neurodegenerative disease. In addition to chromatin regulation, mammalian sirtuins also govern myriad cellular processes through a growing list of enzymatic activities and substrates. This session will highlight new discoveries and directions in Sirtuin research.

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