Sirtuins: New Roles for Sirtuins in Aging and Disease

Sirtuins are NAD+-dependent enzymes related to yeast silent information regulator-2, a histone deacetylase that prevents premature aging through chromatin silencing. Mammalian sirtuins, SIRT1-SIRT7, have key functions that protect against diverse aging-related pathologic states, from cancer to metab...

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Detalles Bibliográficos
Autor principal: Chua, Katrin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7743872/
http://dx.doi.org/10.1093/geroni/igaa057.2650
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author Chua, Katrin
author_facet Chua, Katrin
author_sort Chua, Katrin
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description Sirtuins are NAD+-dependent enzymes related to yeast silent information regulator-2, a histone deacetylase that prevents premature aging through chromatin silencing. Mammalian sirtuins, SIRT1-SIRT7, have key functions that protect against diverse aging-related pathologic states, from cancer to metabolic and neurodegenerative disease. In addition to chromatin regulation, mammalian sirtuins also govern myriad cellular processes through a growing list of enzymatic activities and substrates. This session will highlight new discoveries and directions in Sirtuin research.
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spelling pubmed-77438722020-12-22 Sirtuins: New Roles for Sirtuins in Aging and Disease Chua, Katrin Innov Aging Abstracts Sirtuins are NAD+-dependent enzymes related to yeast silent information regulator-2, a histone deacetylase that prevents premature aging through chromatin silencing. Mammalian sirtuins, SIRT1-SIRT7, have key functions that protect against diverse aging-related pathologic states, from cancer to metabolic and neurodegenerative disease. In addition to chromatin regulation, mammalian sirtuins also govern myriad cellular processes through a growing list of enzymatic activities and substrates. This session will highlight new discoveries and directions in Sirtuin research. Oxford University Press 2020-12-16 /pmc/articles/PMC7743872/ http://dx.doi.org/10.1093/geroni/igaa057.2650 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of The Gerontological Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstracts
Chua, Katrin
Sirtuins: New Roles for Sirtuins in Aging and Disease
title Sirtuins: New Roles for Sirtuins in Aging and Disease
title_full Sirtuins: New Roles for Sirtuins in Aging and Disease
title_fullStr Sirtuins: New Roles for Sirtuins in Aging and Disease
title_full_unstemmed Sirtuins: New Roles for Sirtuins in Aging and Disease
title_short Sirtuins: New Roles for Sirtuins in Aging and Disease
title_sort sirtuins: new roles for sirtuins in aging and disease
topic Abstracts
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7743872/
http://dx.doi.org/10.1093/geroni/igaa057.2650
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