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A novel technique for olfactory bulb measurements
BACKGROUND: To introduce new ways to calculate OB volumes, checking their validity and comparing them to already established technique i.e. OB volumetric based on manual segmentation of OB boundaries. METHODS: Two approaches were used to calculate OB volumes (1) Manual Segmentation using planimetric...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7743925/ https://www.ncbi.nlm.nih.gov/pubmed/33326498 http://dx.doi.org/10.1371/journal.pone.0243941 |
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author | Joshi, Akshita Thaploo, Divesh Yan, Xiaoguang Herrmann, Theresa Khabour, Hudaa Alrahman Hummel, Thomas |
author_facet | Joshi, Akshita Thaploo, Divesh Yan, Xiaoguang Herrmann, Theresa Khabour, Hudaa Alrahman Hummel, Thomas |
author_sort | Joshi, Akshita |
collection | PubMed |
description | BACKGROUND: To introduce new ways to calculate OB volumes, checking their validity and comparing them to already established technique i.e. OB volumetric based on manual segmentation of OB boundaries. METHODS: Two approaches were used to calculate OB volumes (1) Manual Segmentation using planimetric manual contouring; (2) Box-frame method, calculating the parameters based on a box placed around the OB. RESULTS: We calculated OB volumes using both techniques and found comparable outcomes. High inter-observer reliability was found for volumes calculated by both observers. For manual segmentation, Cronbach’s alpha (α) was 0.91 and 0.93 for right and left OB volume, respectively, whereas for the box-frame method α was 0.94 and 0.90 for right and left OB, respectively. CONCLUSIONS: The simple box-frame method of OB volume calculation appears reliable. Its results are comparable to an established technique. |
format | Online Article Text |
id | pubmed-7743925 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-77439252020-12-31 A novel technique for olfactory bulb measurements Joshi, Akshita Thaploo, Divesh Yan, Xiaoguang Herrmann, Theresa Khabour, Hudaa Alrahman Hummel, Thomas PLoS One Research Article BACKGROUND: To introduce new ways to calculate OB volumes, checking their validity and comparing them to already established technique i.e. OB volumetric based on manual segmentation of OB boundaries. METHODS: Two approaches were used to calculate OB volumes (1) Manual Segmentation using planimetric manual contouring; (2) Box-frame method, calculating the parameters based on a box placed around the OB. RESULTS: We calculated OB volumes using both techniques and found comparable outcomes. High inter-observer reliability was found for volumes calculated by both observers. For manual segmentation, Cronbach’s alpha (α) was 0.91 and 0.93 for right and left OB volume, respectively, whereas for the box-frame method α was 0.94 and 0.90 for right and left OB, respectively. CONCLUSIONS: The simple box-frame method of OB volume calculation appears reliable. Its results are comparable to an established technique. Public Library of Science 2020-12-16 /pmc/articles/PMC7743925/ /pubmed/33326498 http://dx.doi.org/10.1371/journal.pone.0243941 Text en © 2020 Joshi et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Joshi, Akshita Thaploo, Divesh Yan, Xiaoguang Herrmann, Theresa Khabour, Hudaa Alrahman Hummel, Thomas A novel technique for olfactory bulb measurements |
title | A novel technique for olfactory bulb measurements |
title_full | A novel technique for olfactory bulb measurements |
title_fullStr | A novel technique for olfactory bulb measurements |
title_full_unstemmed | A novel technique for olfactory bulb measurements |
title_short | A novel technique for olfactory bulb measurements |
title_sort | novel technique for olfactory bulb measurements |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7743925/ https://www.ncbi.nlm.nih.gov/pubmed/33326498 http://dx.doi.org/10.1371/journal.pone.0243941 |
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