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Older age is a protective factor for academic achievements irrespective of treatment modalities for posterior fossa brain tumours in children

The treatment of children with posterior fossa brain tumours (PFBT) impacts their long term functional and imaging outcomes. This study aimed to evaluate academic achievement correlated with long-term sequelae after different PFBT treatment modalities. The study cohort consisted of 110 survivors (me...

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Autores principales: Kruseova, Jarmila, Kovacova, Anna Sarah, Zapotocky, Michal, Sumerauer, David, Pernikova, Ivana, Starkova, Darja, Misove, Adela, Zichova, Andrea, Capek, Vaclav, Langer, Thorsten, am Zehnhoff-Dinnesen, Antoinette, Eckschlager, Tomas, Kyncl, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7743944/
https://www.ncbi.nlm.nih.gov/pubmed/33326475
http://dx.doi.org/10.1371/journal.pone.0243998
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author Kruseova, Jarmila
Kovacova, Anna Sarah
Zapotocky, Michal
Sumerauer, David
Pernikova, Ivana
Starkova, Darja
Misove, Adela
Zichova, Andrea
Capek, Vaclav
Langer, Thorsten
am Zehnhoff-Dinnesen, Antoinette
Eckschlager, Tomas
Kyncl, Martin
author_facet Kruseova, Jarmila
Kovacova, Anna Sarah
Zapotocky, Michal
Sumerauer, David
Pernikova, Ivana
Starkova, Darja
Misove, Adela
Zichova, Andrea
Capek, Vaclav
Langer, Thorsten
am Zehnhoff-Dinnesen, Antoinette
Eckschlager, Tomas
Kyncl, Martin
author_sort Kruseova, Jarmila
collection PubMed
description The treatment of children with posterior fossa brain tumours (PFBT) impacts their long term functional and imaging outcomes. This study aimed to evaluate academic achievement correlated with long-term sequelae after different PFBT treatment modalities. The study cohort consisted of 110 survivors (median age at diagnosis 10.1 years and median time of follow up 13.2 years) who completed hearing questionnaires, neurological assessment and MRI of the brain ≥5 years after the end of treatment. There were three treatment groups. A cisplatin group which underwent cisplatin chemotherapy, radiotherapy and surgery (medulloblastoma N = 40), a radiotherapy group which underwent radiotherapy and surgery (astrocytoma/ependymoma N = 30), and a surgery group (astrocytoma N = 40). Academic achievement was correlated to the age at diagnosis, ototoxicity, Karnofsky score (KS), and MRI findings (Fazekas Score (FS)- treatment related parenchymal changes). For a modelled age at diagnosis of five years, the cisplatin group had lower academic achievements compared to the radiotherapy (p = 0.028) and surgery (p = 0.014) groups. Academic achievements evaluated at a modelled age of 10 years at diagnosis did not significantly differ among the treatment groups. The cisplatin group exhibited a higher occurrence of ototoxicity than the radiotherapy (p<0.019) and surgery groups (p<0.001); however, there was no correlation between ototoxicity and academic achievements (p = 0.722) in older age at diagnosis. The radiotherapy group exhibited lower KS than the surgery group (p<0.001). KS significantly influenced academic achievements in all groups (p<0.000). The cisplatin group exhibited higher FS than the surgery group (p<0.001) while FS did not correlate with academic achievement (p = 0.399). Older age is a protective factor for academic achievements irrespective of a treatment modality.
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spelling pubmed-77439442020-12-31 Older age is a protective factor for academic achievements irrespective of treatment modalities for posterior fossa brain tumours in children Kruseova, Jarmila Kovacova, Anna Sarah Zapotocky, Michal Sumerauer, David Pernikova, Ivana Starkova, Darja Misove, Adela Zichova, Andrea Capek, Vaclav Langer, Thorsten am Zehnhoff-Dinnesen, Antoinette Eckschlager, Tomas Kyncl, Martin PLoS One Research Article The treatment of children with posterior fossa brain tumours (PFBT) impacts their long term functional and imaging outcomes. This study aimed to evaluate academic achievement correlated with long-term sequelae after different PFBT treatment modalities. The study cohort consisted of 110 survivors (median age at diagnosis 10.1 years and median time of follow up 13.2 years) who completed hearing questionnaires, neurological assessment and MRI of the brain ≥5 years after the end of treatment. There were three treatment groups. A cisplatin group which underwent cisplatin chemotherapy, radiotherapy and surgery (medulloblastoma N = 40), a radiotherapy group which underwent radiotherapy and surgery (astrocytoma/ependymoma N = 30), and a surgery group (astrocytoma N = 40). Academic achievement was correlated to the age at diagnosis, ototoxicity, Karnofsky score (KS), and MRI findings (Fazekas Score (FS)- treatment related parenchymal changes). For a modelled age at diagnosis of five years, the cisplatin group had lower academic achievements compared to the radiotherapy (p = 0.028) and surgery (p = 0.014) groups. Academic achievements evaluated at a modelled age of 10 years at diagnosis did not significantly differ among the treatment groups. The cisplatin group exhibited a higher occurrence of ototoxicity than the radiotherapy (p<0.019) and surgery groups (p<0.001); however, there was no correlation between ototoxicity and academic achievements (p = 0.722) in older age at diagnosis. The radiotherapy group exhibited lower KS than the surgery group (p<0.001). KS significantly influenced academic achievements in all groups (p<0.000). The cisplatin group exhibited higher FS than the surgery group (p<0.001) while FS did not correlate with academic achievement (p = 0.399). Older age is a protective factor for academic achievements irrespective of a treatment modality. Public Library of Science 2020-12-16 /pmc/articles/PMC7743944/ /pubmed/33326475 http://dx.doi.org/10.1371/journal.pone.0243998 Text en © 2020 Kruseova et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Kruseova, Jarmila
Kovacova, Anna Sarah
Zapotocky, Michal
Sumerauer, David
Pernikova, Ivana
Starkova, Darja
Misove, Adela
Zichova, Andrea
Capek, Vaclav
Langer, Thorsten
am Zehnhoff-Dinnesen, Antoinette
Eckschlager, Tomas
Kyncl, Martin
Older age is a protective factor for academic achievements irrespective of treatment modalities for posterior fossa brain tumours in children
title Older age is a protective factor for academic achievements irrespective of treatment modalities for posterior fossa brain tumours in children
title_full Older age is a protective factor for academic achievements irrespective of treatment modalities for posterior fossa brain tumours in children
title_fullStr Older age is a protective factor for academic achievements irrespective of treatment modalities for posterior fossa brain tumours in children
title_full_unstemmed Older age is a protective factor for academic achievements irrespective of treatment modalities for posterior fossa brain tumours in children
title_short Older age is a protective factor for academic achievements irrespective of treatment modalities for posterior fossa brain tumours in children
title_sort older age is a protective factor for academic achievements irrespective of treatment modalities for posterior fossa brain tumours in children
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7743944/
https://www.ncbi.nlm.nih.gov/pubmed/33326475
http://dx.doi.org/10.1371/journal.pone.0243998
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