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S-adenosyl-l-homocysteine hydrolase links methionine metabolism to the circadian clock and chromatin remodeling

Circadian gene expression driven by transcription activators CLOCK and BMAL1 is intimately associated with dynamic chromatin remodeling. However, how cellular metabolism directs circadian chromatin remodeling is virtually unexplored. We report that the S-adenosylhomocysteine (SAH) hydrolyzing enzyme...

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Detalles Bibliográficos
Autores principales:	Greco, Carolina Magdalen, Cervantes, Marlene, Fustin, Jean-Michel, Ito, Kakeru, Ceglia, Nicholas, Samad, Muntaha, Shi, Jiejun, Koronowski, Kevin Brian, Forne, Ignasi, Ranjit, Suman, Gaucher, Jonathan, Kinouchi, Kenichiro, Kojima, Rika, Gratton, Enrico, Li, Wei, Baldi, Pierre, Imhof, Axel, Okamura, Hitoshi, Sassone-Corsi, Paolo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2020
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7744083/ https://www.ncbi.nlm.nih.gov/pubmed/33328229 http://dx.doi.org/10.1126/sciadv.abc5629

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