Structure of the human core transcription-export complex reveals a hub for multivalent interactions

The export of mRNA from nucleus to cytoplasm requires the conserved and essential transcription and export (TREX) complex (THO–UAP56/DDX39B–ALYREF). TREX selectively binds mRNA maturation marks and licenses mRNA for nuclear export by loading the export factor NXF1–NXT1. How TREX integrates these mar...

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Detalles Bibliográficos
Autores principales: Pühringer, Thomas, Hohmann, Ulrich, Fin, Laura, Pacheco-Fiallos, Belén, Schellhaas, Ulla, Brennecke, Julius, Plaschka, Clemens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7744094/
https://www.ncbi.nlm.nih.gov/pubmed/33191911
http://dx.doi.org/10.7554/eLife.61503

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7744094/
https://www.ncbi.nlm.nih.gov/pubmed/33191911
http://dx.doi.org/10.7554/eLife.61503

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