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Spatial readout of visual looming in the central brain of Drosophila

Visual systems can exploit spatial correlations in the visual scene by using retinotopy, the organizing principle by which neighboring cells encode neighboring spatial locations. However, retinotopy is often lost, such as when visual pathways are integrated with other sensory modalities. How is spat...

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Autores principales: Morimoto, Mai M, Nern, Aljoscha, Zhao, Arthur, Rogers, Edward M, Wong, Allan M, Isaacson, Mathew D, Bock, Davi D, Rubin, Gerald M, Reiser, Michael B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7744102/
https://www.ncbi.nlm.nih.gov/pubmed/33205753
http://dx.doi.org/10.7554/eLife.57685
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author Morimoto, Mai M
Nern, Aljoscha
Zhao, Arthur
Rogers, Edward M
Wong, Allan M
Isaacson, Mathew D
Bock, Davi D
Rubin, Gerald M
Reiser, Michael B
author_facet Morimoto, Mai M
Nern, Aljoscha
Zhao, Arthur
Rogers, Edward M
Wong, Allan M
Isaacson, Mathew D
Bock, Davi D
Rubin, Gerald M
Reiser, Michael B
author_sort Morimoto, Mai M
collection PubMed
description Visual systems can exploit spatial correlations in the visual scene by using retinotopy, the organizing principle by which neighboring cells encode neighboring spatial locations. However, retinotopy is often lost, such as when visual pathways are integrated with other sensory modalities. How is spatial information processed outside of strictly visual brain areas? Here, we focused on visual looming responsive LC6 cells in Drosophila, a population whose dendrites collectively cover the visual field, but whose axons form a single glomerulus—a structure without obvious retinotopic organization—in the central brain. We identified multiple cell types downstream of LC6 in the glomerulus and found that they more strongly respond to looming in different portions of the visual field, unexpectedly preserving spatial information. Through EM reconstruction of all LC6 synaptic inputs to the glomerulus, we found that LC6 and downstream cell types form circuits within the glomerulus that enable spatial readout of visual features and contralateral suppression—mechanisms that transform visual information for behavioral control.
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spelling pubmed-77441022020-12-21 Spatial readout of visual looming in the central brain of Drosophila Morimoto, Mai M Nern, Aljoscha Zhao, Arthur Rogers, Edward M Wong, Allan M Isaacson, Mathew D Bock, Davi D Rubin, Gerald M Reiser, Michael B eLife Neuroscience Visual systems can exploit spatial correlations in the visual scene by using retinotopy, the organizing principle by which neighboring cells encode neighboring spatial locations. However, retinotopy is often lost, such as when visual pathways are integrated with other sensory modalities. How is spatial information processed outside of strictly visual brain areas? Here, we focused on visual looming responsive LC6 cells in Drosophila, a population whose dendrites collectively cover the visual field, but whose axons form a single glomerulus—a structure without obvious retinotopic organization—in the central brain. We identified multiple cell types downstream of LC6 in the glomerulus and found that they more strongly respond to looming in different portions of the visual field, unexpectedly preserving spatial information. Through EM reconstruction of all LC6 synaptic inputs to the glomerulus, we found that LC6 and downstream cell types form circuits within the glomerulus that enable spatial readout of visual features and contralateral suppression—mechanisms that transform visual information for behavioral control. eLife Sciences Publications, Ltd 2020-11-18 /pmc/articles/PMC7744102/ /pubmed/33205753 http://dx.doi.org/10.7554/eLife.57685 Text en © 2020, Morimoto et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Morimoto, Mai M
Nern, Aljoscha
Zhao, Arthur
Rogers, Edward M
Wong, Allan M
Isaacson, Mathew D
Bock, Davi D
Rubin, Gerald M
Reiser, Michael B
Spatial readout of visual looming in the central brain of Drosophila
title Spatial readout of visual looming in the central brain of Drosophila
title_full Spatial readout of visual looming in the central brain of Drosophila
title_fullStr Spatial readout of visual looming in the central brain of Drosophila
title_full_unstemmed Spatial readout of visual looming in the central brain of Drosophila
title_short Spatial readout of visual looming in the central brain of Drosophila
title_sort spatial readout of visual looming in the central brain of drosophila
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7744102/
https://www.ncbi.nlm.nih.gov/pubmed/33205753
http://dx.doi.org/10.7554/eLife.57685
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