Enhancement of Radiotherapy with Human Mesenchymal Stem Cells Containing Gold Nanoparticles

Radiotherapy is a common approach for the treatment of a wide variety of cancer types. Available data indicate that nanoparticles can enhance the effect of radiotherapy. We report the use of human mesenchymal stem cells to selectively deliver gold nanoparticles (GNPs) to MDA-MB-231 breast tumor xeno...

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Detalles Bibliográficos
Autores principales: Pullambhatla, Mrudula, Rowe, Steven P., Lisok, Ala, Wang, Yuchuan, Todd, Gabriele Putz, Danilkovitch, Alla, Pomper, Martin G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Grapho Publications, LLC 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7744188/
https://www.ncbi.nlm.nih.gov/pubmed/33364427
http://dx.doi.org/10.18383/j.tom.2020.00026
Descripción
Sumario:Radiotherapy is a common approach for the treatment of a wide variety of cancer types. Available data indicate that nanoparticles can enhance the effect of radiotherapy. We report the use of human mesenchymal stem cells to selectively deliver gold nanoparticles (GNPs) to MDA-MB-231 breast tumor xenografts in mice for the purpose of enhancing the effect of radiation therapy. Targeted delivery of GNPs to the tumor site, followed by irradiation of the tumor, enabled control of tumor growth. The results indicate that tumor-selective GNP delivery by human mesenchymal stem cells may represent a viable way to enhance the effectiveness of radiotherapy.

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