Enhancement of Radiotherapy with Human Mesenchymal Stem Cells Containing Gold Nanoparticles

Radiotherapy is a common approach for the treatment of a wide variety of cancer types. Available data indicate that nanoparticles can enhance the effect of radiotherapy. We report the use of human mesenchymal stem cells to selectively deliver gold nanoparticles (GNPs) to MDA-MB-231 breast tumor xeno...

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Autores principales: Pullambhatla, Mrudula, Rowe, Steven P., Lisok, Ala, Wang, Yuchuan, Todd, Gabriele Putz, Danilkovitch, Alla, Pomper, Martin G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Grapho Publications, LLC 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7744188/
https://www.ncbi.nlm.nih.gov/pubmed/33364427
http://dx.doi.org/10.18383/j.tom.2020.00026
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author Pullambhatla, Mrudula
Rowe, Steven P.
Lisok, Ala
Wang, Yuchuan
Todd, Gabriele Putz
Danilkovitch, Alla
Pomper, Martin G.
author_facet Pullambhatla, Mrudula
Rowe, Steven P.
Lisok, Ala
Wang, Yuchuan
Todd, Gabriele Putz
Danilkovitch, Alla
Pomper, Martin G.
author_sort Pullambhatla, Mrudula
collection PubMed
description Radiotherapy is a common approach for the treatment of a wide variety of cancer types. Available data indicate that nanoparticles can enhance the effect of radiotherapy. We report the use of human mesenchymal stem cells to selectively deliver gold nanoparticles (GNPs) to MDA-MB-231 breast tumor xenografts in mice for the purpose of enhancing the effect of radiation therapy. Targeted delivery of GNPs to the tumor site, followed by irradiation of the tumor, enabled control of tumor growth. The results indicate that tumor-selective GNP delivery by human mesenchymal stem cells may represent a viable way to enhance the effectiveness of radiotherapy.
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spelling pubmed-77441882020-12-23 Enhancement of Radiotherapy with Human Mesenchymal Stem Cells Containing Gold Nanoparticles Pullambhatla, Mrudula Rowe, Steven P. Lisok, Ala Wang, Yuchuan Todd, Gabriele Putz Danilkovitch, Alla Pomper, Martin G. Tomography Research Article Radiotherapy is a common approach for the treatment of a wide variety of cancer types. Available data indicate that nanoparticles can enhance the effect of radiotherapy. We report the use of human mesenchymal stem cells to selectively deliver gold nanoparticles (GNPs) to MDA-MB-231 breast tumor xenografts in mice for the purpose of enhancing the effect of radiation therapy. Targeted delivery of GNPs to the tumor site, followed by irradiation of the tumor, enabled control of tumor growth. The results indicate that tumor-selective GNP delivery by human mesenchymal stem cells may represent a viable way to enhance the effectiveness of radiotherapy. Grapho Publications, LLC 2020-12 /pmc/articles/PMC7744188/ /pubmed/33364427 http://dx.doi.org/10.18383/j.tom.2020.00026 Text en © 2020 The Authors. Published by Grapho Publications, LLC http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Pullambhatla, Mrudula
Rowe, Steven P.
Lisok, Ala
Wang, Yuchuan
Todd, Gabriele Putz
Danilkovitch, Alla
Pomper, Martin G.
Enhancement of Radiotherapy with Human Mesenchymal Stem Cells Containing Gold Nanoparticles
title Enhancement of Radiotherapy with Human Mesenchymal Stem Cells Containing Gold Nanoparticles
title_full Enhancement of Radiotherapy with Human Mesenchymal Stem Cells Containing Gold Nanoparticles
title_fullStr Enhancement of Radiotherapy with Human Mesenchymal Stem Cells Containing Gold Nanoparticles
title_full_unstemmed Enhancement of Radiotherapy with Human Mesenchymal Stem Cells Containing Gold Nanoparticles
title_short Enhancement of Radiotherapy with Human Mesenchymal Stem Cells Containing Gold Nanoparticles
title_sort enhancement of radiotherapy with human mesenchymal stem cells containing gold nanoparticles
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7744188/
https://www.ncbi.nlm.nih.gov/pubmed/33364427
http://dx.doi.org/10.18383/j.tom.2020.00026
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