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A Positive Feed Forward Loop between Wnt/β-Catenin and NOX4 Promotes Silicon Dioxide-Induced Epithelial-Mesenchymal Transition of Lung Epithelial Cells
Silicosis is a chronic fibrotic lung disease caused by the accumulation of silica dust in the distal lung. Canonical Wnt signaling and NADPH oxidase 4 (NOX4) have been demonstrated to play a crucial role in the pathogenesis of pulmonary fibrosis including silicosis. However, the underlying mechanism...
Autores principales: | Ma, Jia, Cai, Qian, Yang, Dandan, Yang, Jiali, Xue, Jing, Yu, Miao, Liu, Yingxue, Ma, Fucheng, Li, Feng, Liu, Xiaoming |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7744200/ https://www.ncbi.nlm.nih.gov/pubmed/33376577 http://dx.doi.org/10.1155/2020/3404168 |
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