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Accelerated Dystrophy and Decay of Oligodendrocyte Precursor Cells in the APP/PS1 Model of Alzheimer’s-Like Pathology

Myelin disruption is a feature of natural aging and Alzheimer’s disease (AD). In the CNS, myelin is produced by oligodendrocytes, which are generated throughout life by oligodendrocyte progenitor cells (OPCs). Here, we examined age-related changes in OPCs in APP/PS1 mice, a model for AD-like patholo...

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Detalles Bibliográficos
Autores principales:	Chacon-De-La-Rocha, Irene, Fryatt, Gemma, Rivera, Andrea D., Verkhratsky, Alexei, Raineteau, Olivier, Gomez-Nicola, Diego, Butt, Arthur M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Cellular Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7744306/ https://www.ncbi.nlm.nih.gov/pubmed/33343301 http://dx.doi.org/10.3389/fncel.2020.575082

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