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Effector-Specific Characterization of Brain Dynamics in Manual vs. Oculomotor Go/NoGo Tasks

Motor inhibitory control (IC), the ability to suppress unwanted actions, has been previously shown to rely on domain-general IC processes that are involved in a wide range of IC tasks. Nevertheless, the existence of effector-specific regions and activation patterns that would differentiate manual vs...

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Autores principales: Simonet, Marie, Ruggeri, Paolo, Barral, Jérôme
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7744377/
https://www.ncbi.nlm.nih.gov/pubmed/33343320
http://dx.doi.org/10.3389/fnhum.2020.600667
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author Simonet, Marie
Ruggeri, Paolo
Barral, Jérôme
author_facet Simonet, Marie
Ruggeri, Paolo
Barral, Jérôme
author_sort Simonet, Marie
collection PubMed
description Motor inhibitory control (IC), the ability to suppress unwanted actions, has been previously shown to rely on domain-general IC processes that are involved in a wide range of IC tasks. Nevertheless, the existence of effector-specific regions and activation patterns that would differentiate manual vs. oculomotor response inhibition remains unknown. In this study, we investigated the brain dynamics supporting these two response effectors with the same IC task paradigm. We examined the behavioral performance and electrophysiological activity in a group of healthy young people (n = 25) with a Go/NoGo task using the index finger for the manual modality and the eyes for the oculomotor modality. By computing topographic analysis of variance, we found significant differences between topographies of scalp recorded potentials of the two response effectors between 250 and 325 ms post-stimulus onset. The source estimations localized this effect within the left precuneus, a part of the superior parietal lobule, showing stronger activity in the oculomotor modality than in the manual modality. Behaviorally, we found a significant positive correlation in response time between the two modalities. Our collective results revealed that while domain-general IC processes would be engaged across different response effectors in the same IC task, effector-specific activation patterns exist. In this case, the stronger activation of the left precuneus likely accounts for the increased demand for visual attentional processes in the oculomotor Go/NoGo task.
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spelling pubmed-77443772020-12-18 Effector-Specific Characterization of Brain Dynamics in Manual vs. Oculomotor Go/NoGo Tasks Simonet, Marie Ruggeri, Paolo Barral, Jérôme Front Hum Neurosci Human Neuroscience Motor inhibitory control (IC), the ability to suppress unwanted actions, has been previously shown to rely on domain-general IC processes that are involved in a wide range of IC tasks. Nevertheless, the existence of effector-specific regions and activation patterns that would differentiate manual vs. oculomotor response inhibition remains unknown. In this study, we investigated the brain dynamics supporting these two response effectors with the same IC task paradigm. We examined the behavioral performance and electrophysiological activity in a group of healthy young people (n = 25) with a Go/NoGo task using the index finger for the manual modality and the eyes for the oculomotor modality. By computing topographic analysis of variance, we found significant differences between topographies of scalp recorded potentials of the two response effectors between 250 and 325 ms post-stimulus onset. The source estimations localized this effect within the left precuneus, a part of the superior parietal lobule, showing stronger activity in the oculomotor modality than in the manual modality. Behaviorally, we found a significant positive correlation in response time between the two modalities. Our collective results revealed that while domain-general IC processes would be engaged across different response effectors in the same IC task, effector-specific activation patterns exist. In this case, the stronger activation of the left precuneus likely accounts for the increased demand for visual attentional processes in the oculomotor Go/NoGo task. Frontiers Media S.A. 2020-12-03 /pmc/articles/PMC7744377/ /pubmed/33343320 http://dx.doi.org/10.3389/fnhum.2020.600667 Text en Copyright © 2020 Simonet, Ruggeri and Barral. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Human Neuroscience
Simonet, Marie
Ruggeri, Paolo
Barral, Jérôme
Effector-Specific Characterization of Brain Dynamics in Manual vs. Oculomotor Go/NoGo Tasks
title Effector-Specific Characterization of Brain Dynamics in Manual vs. Oculomotor Go/NoGo Tasks
title_full Effector-Specific Characterization of Brain Dynamics in Manual vs. Oculomotor Go/NoGo Tasks
title_fullStr Effector-Specific Characterization of Brain Dynamics in Manual vs. Oculomotor Go/NoGo Tasks
title_full_unstemmed Effector-Specific Characterization of Brain Dynamics in Manual vs. Oculomotor Go/NoGo Tasks
title_short Effector-Specific Characterization of Brain Dynamics in Manual vs. Oculomotor Go/NoGo Tasks
title_sort effector-specific characterization of brain dynamics in manual vs. oculomotor go/nogo tasks
topic Human Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7744377/
https://www.ncbi.nlm.nih.gov/pubmed/33343320
http://dx.doi.org/10.3389/fnhum.2020.600667
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