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Mucosal IL-4R antagonist HIV vaccination with SOSIP-gp140 booster can induce high-quality cytotoxic CD4(+)/CD8(+) T cells and humoral responses in macaques

Inducing humoral, cellular and mucosal immunity is likely to improve the effectiveness of HIV-1 vaccine strategies. Here, we tested a vaccine regimen in pigtail macaques using an intranasal (i.n.) recombinant Fowl Pox Virus (FPV)-gag pol env-IL-4R antagonist prime, intramuscular (i.m.) recombinant M...

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Detalles Bibliográficos
Autores principales:	Li, Z., Khanna, M., Grimley, S. L., Ellenberg, P., Gonelli, C. A., Lee, Wen Shi, Amarasena, T. H., Kelleher, A. D., Purcell, D. F. J., Kent, S. J., Ranasinghe, C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7744512/ https://www.ncbi.nlm.nih.gov/pubmed/33328567 http://dx.doi.org/10.1038/s41598-020-79172-7

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