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Dynamic profiles of SARS-Cov-2 infection from five Chinese family clusters in the early stage of the COVID-19 pandemic
Although several cases of family clusters with SARS-Cov-2 infection have been reported, there are still limited data preventing conclusions from being drawn regarding the characteristics and laboratory findings in the COVID-19 population within family clusters. In the present study, we retrospective...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7744538/ https://www.ncbi.nlm.nih.gov/pubmed/33328533 http://dx.doi.org/10.1038/s41598-020-79035-1 |
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author | Kong, Xiang-Gen Geng, Jin Zhang, Tao Wang, Bin Wu, An-Zhao Xiao, Di Zhang, Zhao-Hua Liu, Cai-Feng Wang, Li Jiang, Xue-Mei Fan, Yu-Chen |
author_facet | Kong, Xiang-Gen Geng, Jin Zhang, Tao Wang, Bin Wu, An-Zhao Xiao, Di Zhang, Zhao-Hua Liu, Cai-Feng Wang, Li Jiang, Xue-Mei Fan, Yu-Chen |
author_sort | Kong, Xiang-Gen |
collection | PubMed |
description | Although several cases of family clusters with SARS-Cov-2 infection have been reported, there are still limited data preventing conclusions from being drawn regarding the characteristics and laboratory findings in the COVID-19 population within family clusters. In the present study, we retrospectively collected five family clusters with COVID-19 and summarized the dynamic profiles of the clinical characteristics, laboratory findings, immune markers, treatment and prognosis of this population. Furthermore, we also compared clinical and laboratory data between the SARS-Cov-2 infection with family cluster (n = 21) and those without family cluster (n = 16). We demonstrated that the duration of SARS-Cov-2 replication might be varied based on the different family clusters due to their different genetic backgrounds. The onset improved lung radiology might start at the end of the SARS-Cov-2 positive period. Furthermore, the obtained results demonstrated that similar basic characteristics and clinical findings seem to exist between the cases with SARS-Cov-2 and without family clusters. The serum level of ferritin might have a different biological function and be a new biomarker for the family cluster. Further studies with larger numbers of patients are required. |
format | Online Article Text |
id | pubmed-7744538 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-77445382020-12-17 Dynamic profiles of SARS-Cov-2 infection from five Chinese family clusters in the early stage of the COVID-19 pandemic Kong, Xiang-Gen Geng, Jin Zhang, Tao Wang, Bin Wu, An-Zhao Xiao, Di Zhang, Zhao-Hua Liu, Cai-Feng Wang, Li Jiang, Xue-Mei Fan, Yu-Chen Sci Rep Article Although several cases of family clusters with SARS-Cov-2 infection have been reported, there are still limited data preventing conclusions from being drawn regarding the characteristics and laboratory findings in the COVID-19 population within family clusters. In the present study, we retrospectively collected five family clusters with COVID-19 and summarized the dynamic profiles of the clinical characteristics, laboratory findings, immune markers, treatment and prognosis of this population. Furthermore, we also compared clinical and laboratory data between the SARS-Cov-2 infection with family cluster (n = 21) and those without family cluster (n = 16). We demonstrated that the duration of SARS-Cov-2 replication might be varied based on the different family clusters due to their different genetic backgrounds. The onset improved lung radiology might start at the end of the SARS-Cov-2 positive period. Furthermore, the obtained results demonstrated that similar basic characteristics and clinical findings seem to exist between the cases with SARS-Cov-2 and without family clusters. The serum level of ferritin might have a different biological function and be a new biomarker for the family cluster. Further studies with larger numbers of patients are required. Nature Publishing Group UK 2020-12-16 /pmc/articles/PMC7744538/ /pubmed/33328533 http://dx.doi.org/10.1038/s41598-020-79035-1 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Kong, Xiang-Gen Geng, Jin Zhang, Tao Wang, Bin Wu, An-Zhao Xiao, Di Zhang, Zhao-Hua Liu, Cai-Feng Wang, Li Jiang, Xue-Mei Fan, Yu-Chen Dynamic profiles of SARS-Cov-2 infection from five Chinese family clusters in the early stage of the COVID-19 pandemic |
title | Dynamic profiles of SARS-Cov-2 infection from five Chinese family clusters in the early stage of the COVID-19 pandemic |
title_full | Dynamic profiles of SARS-Cov-2 infection from five Chinese family clusters in the early stage of the COVID-19 pandemic |
title_fullStr | Dynamic profiles of SARS-Cov-2 infection from five Chinese family clusters in the early stage of the COVID-19 pandemic |
title_full_unstemmed | Dynamic profiles of SARS-Cov-2 infection from five Chinese family clusters in the early stage of the COVID-19 pandemic |
title_short | Dynamic profiles of SARS-Cov-2 infection from five Chinese family clusters in the early stage of the COVID-19 pandemic |
title_sort | dynamic profiles of sars-cov-2 infection from five chinese family clusters in the early stage of the covid-19 pandemic |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7744538/ https://www.ncbi.nlm.nih.gov/pubmed/33328533 http://dx.doi.org/10.1038/s41598-020-79035-1 |
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