Neutralizing the pathological effects of extracellular histones with small polyanions

Extracellular histones in neutrophil extracellular traps (NETs) or in chromatin from injured tissues are highly pathological, particularly when liberated by DNases. We report the development of small polyanions (SPAs) (~0.9–1.4 kDa) that interact electrostatically with histones, neutralizing their p...

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Detalles Bibliográficos
Autores principales: Meara, Connor H. O’, Coupland, Lucy A., Kordbacheh, Farzaneh, Quah, Benjamin J. C., Chang, Chih-Wei, Simon Davis, David A., Bezos, Anna, Browne, Anna M., Freeman, Craig, Hammill, Dillon J., Chopra, Pradeep, Pipa, Gergely, Madge, Paul D., Gallant, Esther, Segovis, Courtney, Dulhunty, Angela F., Arnolda, Leonard F., Mitchell, Imogen, Khachigian, Levon M., Stephens, Ross W., von Itzstein, Mark, Parish, Christopher R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7744542/
https://www.ncbi.nlm.nih.gov/pubmed/33328478
http://dx.doi.org/10.1038/s41467-020-20231-y

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