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Perianal mucinous adenocarcinoma with dysplastic polyps of the colon: A case report

INTRODUCTION: Perianal mucinous adenocarcinoma is rarely encountered in the setting of anal neoplasms. The rarity of the disease and the paucity of publications on this topic are responsible for a lack of diagnostic and therapeutic guidelines. PRESENTATION OF CASE: An 80-year-old man with mucinous a...

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Autores principales: Feo, Claudio F., Veneroni, Simone, Santoru, Antonio, Cossu, Maria Laura, Scanu, Antonio M., Ginesu, Giorgio C., Porcu, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7744639/
https://www.ncbi.nlm.nih.gov/pubmed/33316613
http://dx.doi.org/10.1016/j.ijscr.2020.12.008
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author Feo, Claudio F.
Veneroni, Simone
Santoru, Antonio
Cossu, Maria Laura
Scanu, Antonio M.
Ginesu, Giorgio C.
Porcu, Alberto
author_facet Feo, Claudio F.
Veneroni, Simone
Santoru, Antonio
Cossu, Maria Laura
Scanu, Antonio M.
Ginesu, Giorgio C.
Porcu, Alberto
author_sort Feo, Claudio F.
collection PubMed
description INTRODUCTION: Perianal mucinous adenocarcinoma is rarely encountered in the setting of anal neoplasms. The rarity of the disease and the paucity of publications on this topic are responsible for a lack of diagnostic and therapeutic guidelines. PRESENTATION OF CASE: An 80-year-old man with mucinous adenocarcinoma of the anal canal associated with dysplastic polyps of the colon was treated by multiple endoscopic polypectomies and abdomino-perineal resection of the rectum. We discuss the management of this rare case from the diagnosis up to one-year follow-up. DISCUSSION: Perianal mucinous adenocarcinoma is a very rare entity frequently combined with chronic fistulas. Inflammatory symptoms may mislead its diagnosis, which is often delayed. The unique association between perianal mucinous adenocarcinoma and dysplastic polyps of the colon, that we have reported, may suggest a secondary etiology. High clinical suspicion is important for early and correct diagnosis, which should be based on endoanal ultrasound and/or magnetic resonance imaging followed by deep tissue biopsies. CONCLUSION: We stress the importance of accumulating such cases in the literature. The understanding of the etiopathogenic mechanisms may lead to the development of novel diagnostic and therapeutic protocols.
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spelling pubmed-77446392020-12-21 Perianal mucinous adenocarcinoma with dysplastic polyps of the colon: A case report Feo, Claudio F. Veneroni, Simone Santoru, Antonio Cossu, Maria Laura Scanu, Antonio M. Ginesu, Giorgio C. Porcu, Alberto Int J Surg Case Rep Case Report INTRODUCTION: Perianal mucinous adenocarcinoma is rarely encountered in the setting of anal neoplasms. The rarity of the disease and the paucity of publications on this topic are responsible for a lack of diagnostic and therapeutic guidelines. PRESENTATION OF CASE: An 80-year-old man with mucinous adenocarcinoma of the anal canal associated with dysplastic polyps of the colon was treated by multiple endoscopic polypectomies and abdomino-perineal resection of the rectum. We discuss the management of this rare case from the diagnosis up to one-year follow-up. DISCUSSION: Perianal mucinous adenocarcinoma is a very rare entity frequently combined with chronic fistulas. Inflammatory symptoms may mislead its diagnosis, which is often delayed. The unique association between perianal mucinous adenocarcinoma and dysplastic polyps of the colon, that we have reported, may suggest a secondary etiology. High clinical suspicion is important for early and correct diagnosis, which should be based on endoanal ultrasound and/or magnetic resonance imaging followed by deep tissue biopsies. CONCLUSION: We stress the importance of accumulating such cases in the literature. The understanding of the etiopathogenic mechanisms may lead to the development of novel diagnostic and therapeutic protocols. Elsevier 2020-12-05 /pmc/articles/PMC7744639/ /pubmed/33316613 http://dx.doi.org/10.1016/j.ijscr.2020.12.008 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Feo, Claudio F.
Veneroni, Simone
Santoru, Antonio
Cossu, Maria Laura
Scanu, Antonio M.
Ginesu, Giorgio C.
Porcu, Alberto
Perianal mucinous adenocarcinoma with dysplastic polyps of the colon: A case report
title Perianal mucinous adenocarcinoma with dysplastic polyps of the colon: A case report
title_full Perianal mucinous adenocarcinoma with dysplastic polyps of the colon: A case report
title_fullStr Perianal mucinous adenocarcinoma with dysplastic polyps of the colon: A case report
title_full_unstemmed Perianal mucinous adenocarcinoma with dysplastic polyps of the colon: A case report
title_short Perianal mucinous adenocarcinoma with dysplastic polyps of the colon: A case report
title_sort perianal mucinous adenocarcinoma with dysplastic polyps of the colon: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7744639/
https://www.ncbi.nlm.nih.gov/pubmed/33316613
http://dx.doi.org/10.1016/j.ijscr.2020.12.008
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