Imaging Neurochemistry and Brain Structure Tracks Clinical Decline and Mechanisms of ALS in Patients

Background: Oxidative stress and protein aggregation are key mechanisms in amyotrophic lateral sclerosis (ALS) disease. Reduced glutathione (GSH) is the most important intracellular antioxidant that protects neurons from reactive oxygen species. We hypothesized that levels of GSH measured by MR spec...

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Detalles Bibliográficos
Autores principales: Andronesi, Ovidiu C., Nicholson, Katharine, Jafari-Khouzani, Kourosh, Bogner, Wolfgang, Wang, Jing, Chan, James, Macklin, Eric A., Levine-Weinberg, Mark, Breen, Christopher, Schwarzschild, Michael A., Cudkowicz, Merit, Rosen, Bruce R., Paganoni, Sabrina, Ratai, Eva-Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7744722/
https://www.ncbi.nlm.nih.gov/pubmed/33343494
http://dx.doi.org/10.3389/fneur.2020.590573

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