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Prolyl isomerization controls activation kinetics of a cyclic nucleotide-gated ion channel

SthK, a cyclic nucleotide-modulated ion channel from Spirochaeta thermophila, activates slowly upon cAMP increase. This is reminiscent of the slow, cAMP-induced activation reported for the hyperpolarization-activated and cyclic nucleotide-gated channel HCN2 in the family of so-called pacemaker chann...

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Detalles Bibliográficos
Autores principales:	Schmidpeter, Philipp A. M., Rheinberger, Jan, Nimigean, Crina M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7744796/ https://www.ncbi.nlm.nih.gov/pubmed/33328472 http://dx.doi.org/10.1038/s41467-020-20104-4

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