Cargando…
Cell Type-Specific Annotation and Fine Mapping of Variants Associated With Brain Disorders
Common genetic variants confer susceptibility to a large number of complex brain disorders. Given that such variants predominantly localize in non-coding regions of the human genome, there is a significant challenge to predict and characterize their functional consequences. More importantly, most av...
Autores principales: | Doostparast Torshizi, Abolfazl, Ionita-Laza, Iuliana, Wang, Kai |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7744805/ https://www.ncbi.nlm.nih.gov/pubmed/33343624 http://dx.doi.org/10.3389/fgene.2020.575928 |
Ejemplares similares
-
Integrative analysis of functional genomic annotations and sequencing data to identify rare causal variants via hierarchical modeling
por: Capanu, Marinela, et al.
Publicado: (2015) -
A computational method for direct imputation of cell type-specific expression profiles and cellular compositions from bulk-tissue RNA-Seq in brain disorders
por: Doostparast Torshizi, Abolfazl, et al.
Publicado: (2021) -
Tissue-wide cell-specific proteogenomic modeling reveals novel candidate risk genes in autism spectrum disorders
por: Doostparast Torshizi, Abolfazl, et al.
Publicado: (2022) -
Cell-Type-Specific Proteogenomic Signal Diffusion for Integrating Multi-Omics Data Predicts Novel Schizophrenia Risk Genes
por: Doostparast Torshizi, Abolfazl, et al.
Publicado: (2020) -
Transcriptional network analysis on brains reveals a potential regulatory role of PPP1R3F in autism spectrum disorders
por: Doostparast Torshizi, Abolfazl, et al.
Publicado: (2018)