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Body Localization of ACE-2: On the Trail of the Keyhole of SARS-CoV-2

The explosion of the new coronavirus (SARS-CoV-2) pandemic has brought the role of the angiotensin converting enzyme 2 (ACE2) back into the scientific limelight. Since SARS-CoV-2 must bind the ACE2 for entering the host cells in humans, its expression and body localization are critical to track the...

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Autores principales: Salamanna, Francesca, Maglio, Melania, Landini, Maria Paola, Fini, Milena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7744810/
https://www.ncbi.nlm.nih.gov/pubmed/33344479
http://dx.doi.org/10.3389/fmed.2020.594495
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author Salamanna, Francesca
Maglio, Melania
Landini, Maria Paola
Fini, Milena
author_facet Salamanna, Francesca
Maglio, Melania
Landini, Maria Paola
Fini, Milena
author_sort Salamanna, Francesca
collection PubMed
description The explosion of the new coronavirus (SARS-CoV-2) pandemic has brought the role of the angiotensin converting enzyme 2 (ACE2) back into the scientific limelight. Since SARS-CoV-2 must bind the ACE2 for entering the host cells in humans, its expression and body localization are critical to track the potential target organ of this infection and to outline disease progression and clinical outcomes. Here, we mapped the physiological body distribution, expression, and activities of ACE2 and discussed its potential correlations and mutal interactions with the disparate symptoms present in SARS-CoV-2 patients at the level of different organs. We highlighted that despite during SARS-CoV-2 infection ACE2-expressing organs may become direct targets, leading to severe pathological manifestations, and subsequent multiple organ failures, the exact mechanism and the potential interactions through which ACE2 acts in these organs is still heavily debated. Further scientific efforts, also considering a personalized approach aimed to consider specific patient differences in the mutual interactions ACE2-SARS-CoV-2 and the long-term health effects associated with COVID-19 are currently mandatory.
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spelling pubmed-77448102020-12-18 Body Localization of ACE-2: On the Trail of the Keyhole of SARS-CoV-2 Salamanna, Francesca Maglio, Melania Landini, Maria Paola Fini, Milena Front Med (Lausanne) Medicine The explosion of the new coronavirus (SARS-CoV-2) pandemic has brought the role of the angiotensin converting enzyme 2 (ACE2) back into the scientific limelight. Since SARS-CoV-2 must bind the ACE2 for entering the host cells in humans, its expression and body localization are critical to track the potential target organ of this infection and to outline disease progression and clinical outcomes. Here, we mapped the physiological body distribution, expression, and activities of ACE2 and discussed its potential correlations and mutal interactions with the disparate symptoms present in SARS-CoV-2 patients at the level of different organs. We highlighted that despite during SARS-CoV-2 infection ACE2-expressing organs may become direct targets, leading to severe pathological manifestations, and subsequent multiple organ failures, the exact mechanism and the potential interactions through which ACE2 acts in these organs is still heavily debated. Further scientific efforts, also considering a personalized approach aimed to consider specific patient differences in the mutual interactions ACE2-SARS-CoV-2 and the long-term health effects associated with COVID-19 are currently mandatory. Frontiers Media S.A. 2020-12-03 /pmc/articles/PMC7744810/ /pubmed/33344479 http://dx.doi.org/10.3389/fmed.2020.594495 Text en Copyright © 2020 Salamanna, Maglio, Landini and Fini. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Salamanna, Francesca
Maglio, Melania
Landini, Maria Paola
Fini, Milena
Body Localization of ACE-2: On the Trail of the Keyhole of SARS-CoV-2
title Body Localization of ACE-2: On the Trail of the Keyhole of SARS-CoV-2
title_full Body Localization of ACE-2: On the Trail of the Keyhole of SARS-CoV-2
title_fullStr Body Localization of ACE-2: On the Trail of the Keyhole of SARS-CoV-2
title_full_unstemmed Body Localization of ACE-2: On the Trail of the Keyhole of SARS-CoV-2
title_short Body Localization of ACE-2: On the Trail of the Keyhole of SARS-CoV-2
title_sort body localization of ace-2: on the trail of the keyhole of sars-cov-2
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7744810/
https://www.ncbi.nlm.nih.gov/pubmed/33344479
http://dx.doi.org/10.3389/fmed.2020.594495
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