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Radiomics Analysis of Magnetic Resonance Imaging Facilitates the Identification of Preclinical Alzheimer’s Disease: An Exploratory Study

Diagnosing Alzheimer’s disease (AD) in the preclinical stage offers opportunities for early intervention; however, there is currently a lack of convenient biomarkers to facilitate the diagnosis. Using radiomics analysis, we aimed to determine whether the features extracted from multiparametric magne...

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Autores principales: Li, Tao-Ran, Wu, Yue, Jiang, Juan-Juan, Lin, Hua, Han, Chun-Lei, Jiang, Jie-Hui, Han, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7744815/
https://www.ncbi.nlm.nih.gov/pubmed/33344457
http://dx.doi.org/10.3389/fcell.2020.605734
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author Li, Tao-Ran
Wu, Yue
Jiang, Juan-Juan
Lin, Hua
Han, Chun-Lei
Jiang, Jie-Hui
Han, Ying
author_facet Li, Tao-Ran
Wu, Yue
Jiang, Juan-Juan
Lin, Hua
Han, Chun-Lei
Jiang, Jie-Hui
Han, Ying
author_sort Li, Tao-Ran
collection PubMed
description Diagnosing Alzheimer’s disease (AD) in the preclinical stage offers opportunities for early intervention; however, there is currently a lack of convenient biomarkers to facilitate the diagnosis. Using radiomics analysis, we aimed to determine whether the features extracted from multiparametric magnetic resonance imaging (MRI) can be used as potential biomarkers. This study was part of the Sino Longitudinal Study on Cognitive Decline project (NCT03370744), a prospective cohort study. All participants were cognitively healthy at baseline. Cohort 1 (n = 183) was divided into individuals with preclinical AD (n = 78) and controls (n = 105) using amyloid-positron emission tomography, and this cohort was used as the training dataset (80%) and validation dataset (the remaining 20%); cohort 2 (n = 51) was selected retrospectively and divided into “converters” and “nonconverters” according to individuals’ future cognitive status, and this cohort was used as a separate test dataset; cohort three included 37 converters (13 from the Alzheimer’s Disease Neuroimaging Initiative) and was used as another test set for independent longitudinal research. We extracted radiomics features from multiparametric MRI scans from each participant, using t-tests, autocorrelation tests, and three independent selection algorithms. We then established two classification models (support vector machine [SVM] and random forest [RF]) to verify the efficiency of the retained features. Five-fold cross-validation and 100 repetitions were carried out for the above process. Furthermore, the acquired stable high-frequency features were tested in cohort three by paired two-sample t-tests and survival analyses to identify whether their levels changed with cognitive decline and impact conversion time. The SVM and RF models both showed excellent classification efficiency, with an average accuracy of 89.7–95.9% and 87.1–90.8% in the validation set and 81.9–89.1% and 83.2–83.7% in the test set, respectively. Three stable high-frequency features were identified, all based on the structural MRI modality: the large zone high-gray-level emphasis feature of the right posterior cingulate gyrus, the variance feature of the left superior parietal gyrus, and the coarseness feature of the left posterior cingulate gyrus; their levels were correlated with amyloid-β deposition and predicted future cognitive decline (areas under the curve 0.649–0.761). In addition, levels of the variance feature at baseline decreased with cognitive decline and could affect the conversion time (p < 0.05). In conclusion, this exploratory study shows that the radiomics features of multiparametric MRI scans could represent potential biomarkers of preclinical AD.
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spelling pubmed-77448152020-12-18 Radiomics Analysis of Magnetic Resonance Imaging Facilitates the Identification of Preclinical Alzheimer’s Disease: An Exploratory Study Li, Tao-Ran Wu, Yue Jiang, Juan-Juan Lin, Hua Han, Chun-Lei Jiang, Jie-Hui Han, Ying Front Cell Dev Biol Cell and Developmental Biology Diagnosing Alzheimer’s disease (AD) in the preclinical stage offers opportunities for early intervention; however, there is currently a lack of convenient biomarkers to facilitate the diagnosis. Using radiomics analysis, we aimed to determine whether the features extracted from multiparametric magnetic resonance imaging (MRI) can be used as potential biomarkers. This study was part of the Sino Longitudinal Study on Cognitive Decline project (NCT03370744), a prospective cohort study. All participants were cognitively healthy at baseline. Cohort 1 (n = 183) was divided into individuals with preclinical AD (n = 78) and controls (n = 105) using amyloid-positron emission tomography, and this cohort was used as the training dataset (80%) and validation dataset (the remaining 20%); cohort 2 (n = 51) was selected retrospectively and divided into “converters” and “nonconverters” according to individuals’ future cognitive status, and this cohort was used as a separate test dataset; cohort three included 37 converters (13 from the Alzheimer’s Disease Neuroimaging Initiative) and was used as another test set for independent longitudinal research. We extracted radiomics features from multiparametric MRI scans from each participant, using t-tests, autocorrelation tests, and three independent selection algorithms. We then established two classification models (support vector machine [SVM] and random forest [RF]) to verify the efficiency of the retained features. Five-fold cross-validation and 100 repetitions were carried out for the above process. Furthermore, the acquired stable high-frequency features were tested in cohort three by paired two-sample t-tests and survival analyses to identify whether their levels changed with cognitive decline and impact conversion time. The SVM and RF models both showed excellent classification efficiency, with an average accuracy of 89.7–95.9% and 87.1–90.8% in the validation set and 81.9–89.1% and 83.2–83.7% in the test set, respectively. Three stable high-frequency features were identified, all based on the structural MRI modality: the large zone high-gray-level emphasis feature of the right posterior cingulate gyrus, the variance feature of the left superior parietal gyrus, and the coarseness feature of the left posterior cingulate gyrus; their levels were correlated with amyloid-β deposition and predicted future cognitive decline (areas under the curve 0.649–0.761). In addition, levels of the variance feature at baseline decreased with cognitive decline and could affect the conversion time (p < 0.05). In conclusion, this exploratory study shows that the radiomics features of multiparametric MRI scans could represent potential biomarkers of preclinical AD. Frontiers Media S.A. 2020-12-03 /pmc/articles/PMC7744815/ /pubmed/33344457 http://dx.doi.org/10.3389/fcell.2020.605734 Text en Copyright © 2020 Li, Wu, Jiang, Lin, Han, Jiang and Han. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Li, Tao-Ran
Wu, Yue
Jiang, Juan-Juan
Lin, Hua
Han, Chun-Lei
Jiang, Jie-Hui
Han, Ying
Radiomics Analysis of Magnetic Resonance Imaging Facilitates the Identification of Preclinical Alzheimer’s Disease: An Exploratory Study
title Radiomics Analysis of Magnetic Resonance Imaging Facilitates the Identification of Preclinical Alzheimer’s Disease: An Exploratory Study
title_full Radiomics Analysis of Magnetic Resonance Imaging Facilitates the Identification of Preclinical Alzheimer’s Disease: An Exploratory Study
title_fullStr Radiomics Analysis of Magnetic Resonance Imaging Facilitates the Identification of Preclinical Alzheimer’s Disease: An Exploratory Study
title_full_unstemmed Radiomics Analysis of Magnetic Resonance Imaging Facilitates the Identification of Preclinical Alzheimer’s Disease: An Exploratory Study
title_short Radiomics Analysis of Magnetic Resonance Imaging Facilitates the Identification of Preclinical Alzheimer’s Disease: An Exploratory Study
title_sort radiomics analysis of magnetic resonance imaging facilitates the identification of preclinical alzheimer’s disease: an exploratory study
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7744815/
https://www.ncbi.nlm.nih.gov/pubmed/33344457
http://dx.doi.org/10.3389/fcell.2020.605734
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