New Insights Into Implications of CTRP3 in Obesity, Metabolic Dysfunction, and Cardiovascular Diseases: Potential of Therapeutic Interventions

Adipose tissue, as the largest endocrine organ, secretes many biologically active molecules circulating in the bloodstream, collectively termed adipocytokines, which not only regulate the metabolism but also play a role in pathophysiological processes. C1q tumor necrosis factor (TNF)-related protein...

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Detalles Bibliográficos
Autores principales: Guo, Bei, Zhuang, Tongtian, Xu, Feng, Lin, Xiao, Li, Fuxingzi, Shan, Su-Kang, Wu, Feng, Zhong, Jia-Yu, Wang, Yi, Zheng, Ming-Hui, Xu, Qiu-Shuang, Ehsan, Ullah Muhammad Hasnain, Yuan, Ling-Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7744821/
https://www.ncbi.nlm.nih.gov/pubmed/33343381
http://dx.doi.org/10.3389/fphys.2020.570270
Descripción
Sumario:Adipose tissue, as the largest endocrine organ, secretes many biologically active molecules circulating in the bloodstream, collectively termed adipocytokines, which not only regulate the metabolism but also play a role in pathophysiological processes. C1q tumor necrosis factor (TNF)-related protein 3 (CTRP3) is a member of C1q tumor necrosis factor-related proteins (CTRPs), which is a paralog of adiponectin. CTRP3 has a wide range of effects on glucose/lipid metabolism, inflammation, and contributes to cardiovascular protection. In this review, we comprehensively discussed the latest research on CTRP3 in obesity, diabetes, metabolic syndrome, and cardiovascular diseases.

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