A Subgroup of Patients With Hospital-acquired Pneumonia Do Not Require Broad-spectrum Gram-negative Antimicrobial Coverage

Among 200 patients developing hospital-acquired pneumonia (HAP) outside the intensive care unit, 61% were treated empirically without broad-spectrum Gram-negative coverage, with clinical cure in 69.7%. Lower disease severity markers (systemic inflammatory response syndrome, hypoxia, tachypnoea, neut...

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Autores principales: Russell, Clark D, Whittaker, Ed, Dee, Dominic P, Farquhar, Eilidh, Saenz de Villaverde, Alba, Evans, Morgan H, Laurenson, Ian F, Mackintosh, Claire L, Cevik, Muge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Online Only Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7744989/
https://www.ncbi.nlm.nih.gov/pubmed/32266388
http://dx.doi.org/10.1093/cid/ciaa391
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author Russell, Clark D
Whittaker, Ed
Dee, Dominic P
Farquhar, Eilidh
Saenz de Villaverde, Alba
Evans, Morgan H
Laurenson, Ian F
Mackintosh, Claire L
Cevik, Muge
author_facet Russell, Clark D
Whittaker, Ed
Dee, Dominic P
Farquhar, Eilidh
Saenz de Villaverde, Alba
Evans, Morgan H
Laurenson, Ian F
Mackintosh, Claire L
Cevik, Muge
author_sort Russell, Clark D
collection PubMed
description Among 200 patients developing hospital-acquired pneumonia (HAP) outside the intensive care unit, 61% were treated empirically without broad-spectrum Gram-negative coverage, with clinical cure in 69.7%. Lower disease severity markers (systemic inflammatory response syndrome, hypoxia, tachypnoea, neutrophilia) and the absence of diabetes mellitus and prior doxycycline treatment (but not the time to HAP onset) identified patients not requiring broad-spectrum Gram-negative coverage.
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spelling pubmed-77449892020-12-22 A Subgroup of Patients With Hospital-acquired Pneumonia Do Not Require Broad-spectrum Gram-negative Antimicrobial Coverage Russell, Clark D Whittaker, Ed Dee, Dominic P Farquhar, Eilidh Saenz de Villaverde, Alba Evans, Morgan H Laurenson, Ian F Mackintosh, Claire L Cevik, Muge Clin Infect Dis Online Only Articles Among 200 patients developing hospital-acquired pneumonia (HAP) outside the intensive care unit, 61% were treated empirically without broad-spectrum Gram-negative coverage, with clinical cure in 69.7%. Lower disease severity markers (systemic inflammatory response syndrome, hypoxia, tachypnoea, neutrophilia) and the absence of diabetes mellitus and prior doxycycline treatment (but not the time to HAP onset) identified patients not requiring broad-spectrum Gram-negative coverage. Oxford University Press 2020-04-08 /pmc/articles/PMC7744989/ /pubmed/32266388 http://dx.doi.org/10.1093/cid/ciaa391 Text en © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Online Only Articles
Russell, Clark D
Whittaker, Ed
Dee, Dominic P
Farquhar, Eilidh
Saenz de Villaverde, Alba
Evans, Morgan H
Laurenson, Ian F
Mackintosh, Claire L
Cevik, Muge
A Subgroup of Patients With Hospital-acquired Pneumonia Do Not Require Broad-spectrum Gram-negative Antimicrobial Coverage
title A Subgroup of Patients With Hospital-acquired Pneumonia Do Not Require Broad-spectrum Gram-negative Antimicrobial Coverage
title_full A Subgroup of Patients With Hospital-acquired Pneumonia Do Not Require Broad-spectrum Gram-negative Antimicrobial Coverage
title_fullStr A Subgroup of Patients With Hospital-acquired Pneumonia Do Not Require Broad-spectrum Gram-negative Antimicrobial Coverage
title_full_unstemmed A Subgroup of Patients With Hospital-acquired Pneumonia Do Not Require Broad-spectrum Gram-negative Antimicrobial Coverage
title_short A Subgroup of Patients With Hospital-acquired Pneumonia Do Not Require Broad-spectrum Gram-negative Antimicrobial Coverage
title_sort subgroup of patients with hospital-acquired pneumonia do not require broad-spectrum gram-negative antimicrobial coverage
topic Online Only Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7744989/
https://www.ncbi.nlm.nih.gov/pubmed/32266388
http://dx.doi.org/10.1093/cid/ciaa391
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