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Somatic alterations and mutational burden are potential predictive factors for metachronous development of early gastric cancer
The risk of developing metachronous gastric cancer (MGC) following curative endoscopic submucosal dissection (ESD) of early gastric cancer (EGC) remains even after eradicating Helicobacter pylori (HP) successfully. We screened initial EGC and adjacent non-cancerous mucosa ESD-resected specimens for...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7745026/ https://www.ncbi.nlm.nih.gov/pubmed/33328548 http://dx.doi.org/10.1038/s41598-020-79195-0 |
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author | Sakuta, Kazuhiro Sasaki, Yu Abe, Yasuhiko Sato, Hidenori Shoji, Masakuni Yaoita, Takao Yagi, Makoto Mizumoto, Naoko Onozato, Yusuke Kon, Takashi Koseki, Ayumi Sato, Sonoko Murakami, Ryoko Miyano, Yuki Ueno, Yoshiyuki |
author_facet | Sakuta, Kazuhiro Sasaki, Yu Abe, Yasuhiko Sato, Hidenori Shoji, Masakuni Yaoita, Takao Yagi, Makoto Mizumoto, Naoko Onozato, Yusuke Kon, Takashi Koseki, Ayumi Sato, Sonoko Murakami, Ryoko Miyano, Yuki Ueno, Yoshiyuki |
author_sort | Sakuta, Kazuhiro |
collection | PubMed |
description | The risk of developing metachronous gastric cancer (MGC) following curative endoscopic submucosal dissection (ESD) of early gastric cancer (EGC) remains even after eradicating Helicobacter pylori (HP) successfully. We screened initial EGC and adjacent non-cancerous mucosa ESD-resected specimens for somatic variants of 409 cancer-related genes, assessing their mutational burden (MB) to predict molecular markers for metachronous post-ESD development. We compared variants between ten patients diagnosed with MGC more than 3 years after ESD and ten age-matched patients who did not have MGC developments after successful HP eradication. We found no significant background differences between the two groups. In adjacent non-cancerous mucosa, the MB tended to be higher in the patients with metachronous developments than in the others. Somatic genomic alterations of RECQL4, JAK3, ARID1A, and MAGI1 genes were significantly associated with MGC development. The criteria including both the MB and their variants, which had potential significant values for predicting MGC. In conclusion, combined of assessing specific somatic variants and MB may be useful for predicting MGC development. This study included a limited number of subjects; however, our novel findings may encourage further exploration of the significance of the molecular features of EGC that predict MGC development, thereby promoting focused follow-up strategies and helping elucidate the mechanisms. |
format | Online Article Text |
id | pubmed-7745026 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-77450262020-12-18 Somatic alterations and mutational burden are potential predictive factors for metachronous development of early gastric cancer Sakuta, Kazuhiro Sasaki, Yu Abe, Yasuhiko Sato, Hidenori Shoji, Masakuni Yaoita, Takao Yagi, Makoto Mizumoto, Naoko Onozato, Yusuke Kon, Takashi Koseki, Ayumi Sato, Sonoko Murakami, Ryoko Miyano, Yuki Ueno, Yoshiyuki Sci Rep Article The risk of developing metachronous gastric cancer (MGC) following curative endoscopic submucosal dissection (ESD) of early gastric cancer (EGC) remains even after eradicating Helicobacter pylori (HP) successfully. We screened initial EGC and adjacent non-cancerous mucosa ESD-resected specimens for somatic variants of 409 cancer-related genes, assessing their mutational burden (MB) to predict molecular markers for metachronous post-ESD development. We compared variants between ten patients diagnosed with MGC more than 3 years after ESD and ten age-matched patients who did not have MGC developments after successful HP eradication. We found no significant background differences between the two groups. In adjacent non-cancerous mucosa, the MB tended to be higher in the patients with metachronous developments than in the others. Somatic genomic alterations of RECQL4, JAK3, ARID1A, and MAGI1 genes were significantly associated with MGC development. The criteria including both the MB and their variants, which had potential significant values for predicting MGC. In conclusion, combined of assessing specific somatic variants and MB may be useful for predicting MGC development. This study included a limited number of subjects; however, our novel findings may encourage further exploration of the significance of the molecular features of EGC that predict MGC development, thereby promoting focused follow-up strategies and helping elucidate the mechanisms. Nature Publishing Group UK 2020-12-16 /pmc/articles/PMC7745026/ /pubmed/33328548 http://dx.doi.org/10.1038/s41598-020-79195-0 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Sakuta, Kazuhiro Sasaki, Yu Abe, Yasuhiko Sato, Hidenori Shoji, Masakuni Yaoita, Takao Yagi, Makoto Mizumoto, Naoko Onozato, Yusuke Kon, Takashi Koseki, Ayumi Sato, Sonoko Murakami, Ryoko Miyano, Yuki Ueno, Yoshiyuki Somatic alterations and mutational burden are potential predictive factors for metachronous development of early gastric cancer |
title | Somatic alterations and mutational burden are potential predictive factors for metachronous development of early gastric cancer |
title_full | Somatic alterations and mutational burden are potential predictive factors for metachronous development of early gastric cancer |
title_fullStr | Somatic alterations and mutational burden are potential predictive factors for metachronous development of early gastric cancer |
title_full_unstemmed | Somatic alterations and mutational burden are potential predictive factors for metachronous development of early gastric cancer |
title_short | Somatic alterations and mutational burden are potential predictive factors for metachronous development of early gastric cancer |
title_sort | somatic alterations and mutational burden are potential predictive factors for metachronous development of early gastric cancer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7745026/ https://www.ncbi.nlm.nih.gov/pubmed/33328548 http://dx.doi.org/10.1038/s41598-020-79195-0 |
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